All N=4 conformal supergravities in four space-time dimensions are constructed. These are the only N=4 supergravity theories whose actions are invariant under off-shell supersymmetry. They are encoded in terms of a holomorphic function that is homogeneous of zeroth degree in scalar fields that parametrize an SU(1,1)/U(1) coset space. When this function equals a constant the Lagrangian is invariant under continuous SU(1,1) transformations. The construction of these higher-derivative invariants also opens the door to various applications for nonconformal theories.
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http://dx.doi.org/10.1103/PhysRevLett.118.081602 | DOI Listing |
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA. Electronic address:
The integrated stress response (ISR) is a cellular defense mechanism activated under stress conditions. When the ISR is activated, it slows the production of proteins, the building blocks that cells need to function. Trans-integrated stress response inhibitor (trans-ISRIB) is a compound that can reverse the effects of ISR activation, showing promise for treating neurodegenerative diseases.
View Article and Find Full Text PDFThe title compound, CHClNO, is significantly distorted from planarity, with a twist angle between the planes through the hy-droxy-benzene and acetamide groups being 23.5 (2)°. This conformation is supported by intra-molecular C-H⋯O and N-H⋯Cl contacts.
View Article and Find Full Text PDFActa Crystallogr E Crystallogr Commun
October 2024
Department of Organic Chemistry University of Madras, Guindy Campus Chennai-600 025 Tamilnadu India.
Two new phenyl-sulfonyl-indole derivatives, namely, -{[3-bromo-1-(phenyl-sulfon-yl)-1-indol-2-yl]meth-yl}--(4-bromo-3-meth-oxy-phen-yl)benzene-sulfonamide, CHBrNOS, (), and ,-bis-{[3-bromo-1-(phenyl-sulfon-yl)-1-indol-2-yl]meth-yl}benzene-sulfonamide, CHBrNOS, (), reveal the impact of intra-molecular π-π inter-actions of the indole moieties as a factor not only governing the conformation of ,-bis-(1-indol-2-yl)meth-yl)amines, but also significantly influencing the crystal patterns. For , the crystal packing is dominated by C-H⋯π and π-π bonding, with a particular significance of mutual indole-indole inter-actions. In the case of , the mol-ecules adopt short intra-molecular π-π inter-actions between two nearly parallel indole ring systems [with the centroids of their pyrrole rings separated by 3.
View Article and Find Full Text PDFJ Am Chem Soc
December 2024
School of Materials Science and Engineering, Nankai University, Tianjin 300350, P. R. China.
Developing axial coordination engineering of single-atom nanozymes (SAzymes), directly regulating the axial coordination environment of the catalytic site, and optimizing the axial adsorption are meaningful and challenging for boosting the enzyme-like activities. Herein, the axial chlorination engineering of SAzyme with the Fe-NCl catalytic site (Fe-NCl/CNCl) was first proposed, exhibiting superior peroxidase-like activity compared to the traditional Fe-N/CN SAzyme with Fe-N site. The maximal reaction velocity (4.
View Article and Find Full Text PDFNat Prod Res
November 2024
Department of Microbiology, Assam University, Silchar, Assam, India.
Extended-spectrum β-lactamases (ESBL) producing enterobacteriales are a major global health concern since they often result in the ineffectiveness of empirical antibiotic therapy with β-lactams. This study aims to identify potential medicinal plants that can inhibit β-lactamase and subsequently enhance the activity of the β-lactams against resistant bacterial strains. A synergistic study of extract exhibited good synergistic activity against a CTX-M-producing organism, which was confirmed using an agar-based diffusion bioassay method.
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