PEGylated Perylenemonoimide-Dithienylethene for Super-Resolution Imaging of Liposomes.

ACS Appl Mater Interfaces

Wuhan National Laboratory for Optoelectronics, College of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.

Published: March 2017

AI Article Synopsis

  • Developed a new photoswitchable fluorophore called PEG-PMI-DTE that is both amphiphilic and resistant to fatigue.
  • The fluorophore allows for significant changes in fluorescence and shows bistable photochromism.
  • It can be used to visualize small liposome structures under super-resolution fluorescent microscopy with a high optical resolution of 30 nm.

Article Abstract

We have designed and synthesized an amphiphilic photoswitchable fluorophore, PEGylated perylenemonoimide-dithienylethene (PEG-PMI-DTE), which exhibits evident bistable photochromism, fluorescence switching, and fatigue resistance. The fine nanostructures of liposomes can be observed directly under super-resolution fluorescent microscopy by aid of the amphiphilic photoswitchable fluorophore as a staining agent, with an optical resolution of 30 nm.

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Source
http://dx.doi.org/10.1021/acsami.6b15076DOI Listing

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