A new isoquinoline, 1,5-dihydroxy-4-methoxyisoquinoline (1), was obtained from Scolopendra subspinipes mutilans. Compound 1 showed moderate cytotoxicity on tumour cells with IC values ranging from 13 to 26 μm against five esophageal squamous cancer cells whereas low cytotoxicity against normal human esophageal epithelial cells. Isoquinoline ring oxidized at C(1), C(4), and C(5) can enhance its cytotoxicity. In addition, compound 1 showed potent inhibitory effect (inhibition rate > 50% at 13 μm) on cell migration in human umbilical vein endothelial cells. This article mainly studies the structure and activity of 1, and more modification of 1 as a potential anticancer agent.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cbdv.201600478 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Systemic anaphylaxis following centipede envenomation: A case report and review of literature.
J Family Med Prim Care
November 2024
Department of Medicine, Healthway Hospitals Pvt. Ltd. Goa, India.
Centipede envenomation is usually not life-threatening. They usually present with local symptoms of swelling and pain. Centipede venoms contain large amounts of allergenic proteins that can pose a risk of allergic complications following the bite.
View Article and Find Full Text PDFPore blocking mechanisms of centipede toxin SsTx-4 on the inwardly rectifying potassium channels.
Eur J Pharmacol
December 2024
The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of life Sciences, Hunan Normal University, Changsha, China. Electronic address:
The peptide toxin SsTx-4 derived from venom of centipede Scolopendra subspinipes mutilans was characterized as a potent antagonist of the inwardly rectifying potassium (Kir) channel subtypes Kir1.1, Kir4.1, and Kir6.
View Article and Find Full Text PDFArticle Synopsis
- The paper presents new research and data on scolopendromorph centipedes specifically from the island of Martinique.
- It includes new illustrated descriptions for some centipede taxa and introduces a new species, Cryptops (Trigonocryptops) amicitia, along with discussions on its classification.
- The study also offers an updated checklist of Martinique's scolopendromorph centipedes, detailing their distributions, ecological information, and insights into their taxonomy.
Soufeng sanjie formula alleviates osteoarthritis by inhibiting macrophage M1 polarization and modulating intestinal metabolites.
J Ethnopharmacol
January 2025
Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, 324000, China; Shandong Academy of Chinese Medicine, Jinan, 250014, China; Animal-Derived Chinese Medicine and Functional Peptides International Collaboration Joint Laboratory, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China; State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China. Electronic address:
Ethnopharmacological Relevance: Osteoarthritis (OA) is defined as "bone bi" disease based on clinical symptoms in Chinese medicine. Soufeng sanjie formula (SF) is a traditional formula for treating "bone bi" disease, which consists of Scolopendra (dried body of Scolopendra subspinipes mutilans L. Koch) (0.
View Article and Find Full Text PDFIdentification of two new species of (Chilopoda, Geophilomorpha, Mecistocephalidae) from southern China and the re-description of Pocock, 1895.
Zookeys
November 2024
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China Tianjin Agricultural University Tianjin China.
Newport, 1843 is the most diverse genus in the family Mecistocephalidae; however, only two species have been recorded in mainland China to date. Therefore, taxonomic research on Chinese needs further research. In this study, the species diversity of in southern China was investigated using the mitochondrial marker COI integrated with morphological evidence.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!