AI Article Synopsis
- - The study focuses on creating polyion complex (PIC) particles for delivering Polymyxin B (Pol-B), an antibiotic used against hard-to-treat gram-negative bacteria.
- - Researchers identified various conditions to efficiently combine Pol-B with poly(styrene sulphonate) (PSS) to produce stable colloidal PIC particles with different ratios of Pol-B to PSS.
- - The stability of these PIC particles was tested in conditions similar to those found in the human body, and their antimicrobial effects against a specific gram-negative bacterium were preliminarily evaluated.
Article Abstract
Here, we describe novel polyion complex (PIC) particles for the delivery of Polymyxin B (Pol-B), an antimicrobial peptide currently used in the clinic as a last resort antibiotic against multidrug-resistant gram-negative bacteria. A range of conditions for the controlled assembly of Pol-B with poly(styrene sulphonate) (PSS) has been identified which let us prepare stable colloidal PIC particles. This way, PIC particles containing different Pol-B:PSS ratios have been prepared and their stability under simulated physiological conditions (. pH, osmotic pressure and temperature) characterised. Furthermore, preliminary evaluation of the antimicrobial activity of these Pol-B containing PIC particles has been performed, by monitoring their effect on the growth of , an opportunistic gram-negative bacterium.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327956 | PMC |
| http://dx.doi.org/10.1016/j.eurpolymj.2016.08.023 | DOI Listing |
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