AI Article Synopsis
- - SLEV has reemerged in South America, leading to encephalitis outbreaks in the early 2000s, prompting research into its virulence using two mouse models inoculated with different virus strains.
- - The epidemic strain CbaAr-4005 caused severe symptoms in mice, such as high viral levels, widespread tissue invasion, and significant inflammation in organs like the lungs and brain, resulting in illness and death.
- - In contrast, the non-epidemic strain CorAn-9275 did not produce any disease symptoms or viral replication in the mice, showing effective immune responses with maintained germinal centers and B cell function.
Article Abstract
Saint Louis encephalitis virus (SLEV) reemerged in South America, and caused encephalitis outbreaks at the beginning of the 21st century. To enhance our knowledge about SLEV virulence, we performed comparative pathogenesis studies in Swiss albino mice inoculated with two different variants, the epidemic strain CbaAr-4005 and the non-epidemic strain CorAn-9275. Only the infection of mice with SLEV strain CbaAr-4005 resulted in high viremia, invasion of peripheral tissues including the lungs, kidney, and spleen, and viral neuroinvasion. This was associated with inflammatory pathology in the lungs, spleen, and brain as well as morbidity and mortality. In contrast, neither signs of desease nor viral replication were observed in mice infected with strain CorAn-9275. Interestingly, important loss of B cells and development of altered germinal centers (GC) were detected in the spleen of mice infected with strain CbaAr-4005, whereas mice infected with SLEV CorAn-9275 developed prominent GC with conserved follicular architecture, and neutralizing antibodies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.virol.2017.02.023 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Silent St. Louis encephalitis virus circulation evidence by a haemovigilance survey in a centralized blood bank.
J Public Health (Oxf)
November 2024
Fundación Banco Central de Sangre, 5000 Córdoba, Córdoba, Argentina.
Background: Saint Louis encephalitis virus (SLEV) re-emergence and its geographical expansion, evidenced by its emergence in previously unaffected areas, have raised significant public health concerns. We aimed to show the usefulness of haemovigilance as an effective tool to fill arboviruses surveillance gaps to track trends and identify hotspots.
Methods: Within the framework of a blood bank haemovigilance program, we performed a survey to evaluate the potential threat of circulating mosquito-borne infections for transfusion safety.
Neuronal Degeneration in Mice Induced by an Epidemic Strain of Saint Louis Encephalitis Virus Isolated in Argentina.
Front Microbiol
June 2018
Inmunología, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Saint Louis encephalitis virus (SLEV) is a neglected flavivirus that causes severe neurological disorders. The epidemic strain of SLEV, CbaAr-4005, isolated during an outbreak in Córdoba city (Argentina), causes meningitis and encephalitis associated with neurological symptoms in a murine experimental model. Here, we identified the affected brain areas and the damage triggered by this neurotropic arbovirus.
View Article and Find Full Text PDFTissue tropism of Saint Louis encephalitis virus: Histopathology triggered by epidemic and non-epidemic strains isolated in Argentina.
Virology
May 2017
Laboratorio de Arbovirus, Instituto de Virología ''Dr. J. M. Vanella'', Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gómez S/N. CP, 5016, Ciudad Universitaria, Córdoba, Argentina; Instituto de Investigaciones Biológicas y Tecnológicas, CONICET-Universidad Nacional de Córdoba, Av. Velez Sarfield 1611, CP: 5016, Córdoba, Argentina. Electronic address:
Saint Louis encephalitis virus (SLEV) reemerged in South America, and caused encephalitis outbreaks at the beginning of the 21st century. To enhance our knowledge about SLEV virulence, we performed comparative pathogenesis studies in Swiss albino mice inoculated with two different variants, the epidemic strain CbaAr-4005 and the non-epidemic strain CorAn-9275. Only the infection of mice with SLEV strain CbaAr-4005 resulted in high viremia, invasion of peripheral tissues including the lungs, kidney, and spleen, and viral neuroinvasion.
View Article and Find Full Text PDFVirulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina.
Mem Inst Oswaldo Cruz
April 2014
Laboratorio de Arbovirus, Instituto de Virología Dr JM Vanella, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Saint Louis encephalitis virus caused an outbreak of febrile illness and encephalitis cases in Córdoba, Argentina, in 2005. During this outbreak, the strain CbaAr-4005 was isolated from Culex quinquefasciatus mosquitoes. We hypothesised that this epidemic variant would be more virulent in a mouse model than two other non-epidemic strains (78V-6507 and CorAn-9275) isolated under different epidemiological conditions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!