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| http://dx.doi.org/10.1080/21505594.2017.1300735 | DOI Listing |
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Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells.
BMC Genomics
March 2025
Department of Biology, University of Kentucky, Lexington, KY, USA.
Background: The regulation of chromatin accessibility is essential in eukaryotic cells as one of several mechanisms that ensure gene activation occurs at appropriate times and in appropriate cell types. Accordingly, mutations in chromatin remodeling proteins are linked to many different developmental disorders and cancers. One example of a chromatin protein that has been linked to both developmental abnormalities and cancer is BPTF/NURF301, the largest subunit of the Nucleosome Remodeling Factor (NuRF) complex.
View Article and Find Full Text PDFExtracellular Vesicles Derived From Regenerating Tissue Promote Stem Cell Proliferation in the Planarian .
J Extracell Biol
March 2025
Genes and Human Disease Research Program Oklahoma Medical Research Foundation Oklahoma City Oklahoma USA.
Extracellular vesicles (EVs) are secreted nanoparticles composed of a lipid bilayer that carry lipid, protein, and nucleic acid cargo between cells as a mode of intercellular communication. Although EVs can promote tissue repair in mammals, their roles in animals with greater regenerative capacity are not well understood. Planarian flatworms are capable of whole-body regeneration due to pluripotent somatic stem cells called neoblasts that proliferate in response to injury.
View Article and Find Full Text PDFPlanarian as an Animal Model for Experimental Acute Seizure.
J Vis Exp
February 2025
Department of Biomedical and Translational Sciences, Macon and Joan Brock Virginia Health Sciences Eastern Virginia Medical School, Old Dominion University;
Epilepsy is among the most prevalent neurological disorders characterized by recurring spontaneous seizures. Seizures represent a clinical manifestation of uncontrolled, excessively synchronized neural cell activity. The extent of brain damage from seizures depends on their duration and intensity.
View Article and Find Full Text PDFPhosphoproteomic analysis of X-ray-irradiated planarians provides novel insights into the DNA damage response.
Int J Biol Macromol
April 2025
College of Life Science, Henan Normal University, Xinxiang 453007, Henan Province, PR China. Electronic address:
Phosphorylation plays a crucial role in the cellular response to radiation and cancer therapies, yet phosphoproteomics studies in planarians remain underexplored despite the organism's remarkable regenerative capacities. This study utilized advanced ion mobility mass spectrometry for 4D-label-free quantitative proteomics to identify phosphorylation sites associated with irradiation in planarians. A total of 33,284 phosphorylation sites from 15,505 phosphorylated peptides and 4710 unique phosphoproteins were identified.
View Article and Find Full Text PDFNeuropeptide-mediated temporal sensory filtering in a primordial nervous system.
bioRxiv
December 2024
Department of Bioengineering, Stanford University.
Unlabelled: Sensory filtering - prioritizing relevant stimuli while ignoring irrelevant ones - is crucial for animals to adapt and survive in complex environments. While this phenomenon has been primarily studied in organisms with complex nervous systems, it remains unclear whether simpler organisms also possess such capabilities. Here, we studied temporal information processing in , a freshwater planarian flatworm with a primitive nervous system.
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