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Background & Objectives: Haemophilus influenzae is an important cause of mortality and morbidity among young children in developing countries. Increasing incidence of antibiotic resistance especially production of extended spectrum beta lactamase (ESBL) has made treatment and management of H. influenzae infection more difficult.

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Background: There is increasing concern regarding antimicrobial resistance in Pakistan. Data are limited on the prevalence, pattern of resistance and risk factors associated with resistant organisms. This Study was done to address these issues as they relate to common infection of male/female.

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The alteration of serum complement profile following therapy with various antibiotics was studied in 23 hospitalized patients and in 10 human volunteers. Tetracycline, chloromycetin, ampicillin, and streptomycin reduced serum CH50 and C3 levels in the inpatients. Tetracycline administration for three consecutive days in four normal subjects decreased serum CH50, C1q, C3, and C4 levels on day 4.

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