In vitro studies into the interaction of polyhedral oligomeric silsesquioxane (POSS) trisilanols with porcine and human red blood cells (erythrocytes), and mouse fibroblasts is reported. The observations are in agreement with previously reported erythrocyte activity of silanol containing minerals. However the multifunctionality imparted by the POSS silanols provides for their expansion of utility in traumatic hemorrhage and wound care. Further, in vitro tissue studies of i-octyltrisilanol POSS cages are in agreement with reported findings of related POSS serving as tissue scaffolds by providing cellular binding sites and porosity for cellular taxis. The resulting effect is increased rates of tissue healing.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c7dt00487g | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Silsesquioxane Cages under Solvent Regimen: The Influence of the Solvent on the Hydrolysis and Condensation of Alkoxysilane.
Inorg Chem
May 2024
Faculty of Chemistry, University of Wrocław, 14 F. Joliot-Curie, 50-383 Wrocław, Poland.
This study investigates the formation mechanisms of oligomeric phenyl silanols, focusing on polyhedral oligomeric silsesquioxane (POSS) and double-decker silsesquioxane (DDSQ) derivatives. Combining literature reports and crystal structures of solvated derivatives obtained in our laboratory, we show that the solvent choice significantly influences their structures. POSS-based silanols prefer aprotic solvents like THF, preserving dimerization, while double-deckers form stable architectures in protic solvents like isopropanol.
View Article and Find Full Text PDFB(CF)-Catalyzed Dehydrocoupling of POSS Silanols with Hydrosilanes: A Metal-Free Strategy for Effecting Functionalization of Silsesquioxanes.
Inorg Chem
July 2020
Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
We report a highly effective metal-free catalytic procedure for the functionalization of silsesquioxanes via dehydrocoupling of various POSS silanols with hydrosilanes in the presence of commercially available tris(pentafluorophenyl)borane B(CF). This approach enables the unprecedented one-pot synthesis of valuable silsesquioxane derivatives under mild conditions, with no corrosive byproducts formed in the process.
View Article and Find Full Text PDFSynthesis of a poly(sulfobetaine-co-polyhedral oligomeric silsesquioxane) hybrid monolith via an in-situ ring opening quaternization for use in hydrophilic interaction capillary liquid chromatography.
Mikrochim Acta
January 2020
Key Laboratory of Phytochemical R&D of Hunan Province, Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha, 410081, China.
An in-situ approach is described for synthesis of poly(sulfobetaine-co-polyhedral oligomeric silsesquioxane) [poly(sulfobetaine-co-POSS)] that can be used in a hybrid monolithic column as a hydrophilic liquid chromatography (HILIC) stationary phase. Synthesis involves (a) radical polymerization of octa(propyl methacrylate)-polyhedral oligomeric silsesquioxane (MA-POSS) and organic monomers such as dimethylaminopropyl methacrylate or vinyl imidazole, and (b) in-situ ring-opening quaternization between 1,4-butane sultone and the organic monomers. The sulfobetaine groups are generated in-situ monolith.
View Article and Find Full Text PDFKinetic and Binding Studies Reveal Cooperativity and Off-Cycle Competition for H-Bonding Catalysis with Silsesquioxane Silanols.
Chemistry
November 2019
Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA, USA.
The catalytic activity, kinetics, and quantification of H-bonding ability of incompletely condensed polyhedral oligomeric silsesquioxane (POSS) silanols are reported. POSS-triols, a homogeneous model for vicinal silica surface sites, exhibit enhanced H-bonding compared with other silanols and alcohols as quantified using a P NMR probe. Evaluation of a Friedel-Crafts addition reaction shows that phenyl-POSS-triol is active as an H-bond donor catalyst whereas other POSS silanols studied are not.
View Article and Find Full Text PDFThe Preparation and Chemical Structure Analysis of Novel POSS-Based Porous Materials.
Materials (Basel)
June 2019
College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
In this work, we reported the preparation and chemical analysis of novel polyhedral oligomeric silsesquioxane (POSS)-based porous materials, which were prepared according to Friedel-Crafts chloromethylation by using aluminum chloride as the catalyst and dichloromethane as the solvent. Through controlling the treatment solvent (water or methanol) and kinds of POSS, several materials with different morphologies were conveniently obtained. The chemical structure of porous materials was systematically characterized by Fourier-transform infrared (FTIR) spectra, Si Nuclear Magnetic Resonance (NMR), C NMR, and X-ray photoelectron spectroscopy (XPS).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!