AI Article Synopsis
- Subacute cutaneous lupus erythematosus (SCLE) features non-scarring skin plaques, mostly in sun-exposed areas, and is linked to specific autoantibodies, being either idiopathic or drug-induced.
- Recent studies have highlighted antiestrogen therapies, like letrozole, as potential triggers for SCLE and other autoimmune disorders, especially in breast cancer patients.
- A case study illustrated a 42-year-old woman who developed SCLE after taking letrozole, with symptom remission upon stopping the medication, emphasizing the need for oncologists to monitor for autoimmune reactions in patients on aromatase inhibitors.
Article Abstract
Subacute cutaneous lupus erythematosus (SCLE) is characterized by particular cutaneous manifestations such as non-scaring plaques mainly in sunlight exposed parts of the body along with specific serum autoantibodies (i.e. antinuclear antibodies (ANA), Ro/SSa, La/SSb). It is considered either idiopathic or drug induced. The role of chemotherapeutic agents in causing SCLE has been investigated with the taxanes being the most common anticancer agents. However, recent data emerging point toward antiestrogen therapies as a causative factor not only for SCLE but also for a variety of autoimmune disorders. This is a report of a case of a 42 year old woman who developed clinical manifestations of SCLE after letrozole treatment in whom remission of the cutaneous manifestations was noticed upon discontinuation of the drug. In addition, an extensive review of the English literature has been performed regarding the association of antiestrogen therapy with autoimmune disorders. In conclusion, Oncologists should be aware of the potential development of autoimmune reactions in breast cancer patients treated with aromatase inhibitors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328027 | PMC |
| http://dx.doi.org/10.1016/j.jare.2016.04.001 | DOI Listing |
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