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LAMP2-FLOT2 interaction enhances autophagosome-lysosome fusion to protect the septic heart in response to ILC2.
Autophagy
March 2025
Department of Critical Care Medicine and Emergency, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cardiac dysfunction is a serious complication of sepsis-induced multiorgan failure in intensive care units and is characterized by an uncontrolled immune response to overwhelming infection. Type 2 innate lymphoid cells (ILC2s), as a part of the innate immune system, play a crucial role in the inflammatory process of heterogeneous cardiac disorders. However, the role of ILC2 in regulating sepsis-induced cardiac dysfunction and its underlying mechanism remain unknown.
View Article and Find Full Text PDFEvaluation Of The Benefits Of Respirator Breathing And Vomiting Training and Dynamic Core Training On Improving Respiratory Muscle Strength.
Respir Med
March 2025
Affiliated Hospital of NorCuan Medical College,Nanchong, 637000. Electronic address:
Background And Objective: Respiratory muscle training is a widely used method in clinical diagnosis and medical treatment. Due to the fact that the respiratory muscles are located in the core area that supports the human body. Therefore, understanding how to train the core muscle group in the correct way is of great significance in improving physical fitness and reducing the occurrence of sports injuries.
View Article and Find Full Text PDFInfluence of genotype and environment on piglet vitality and metabolic state during the suckling period of divergent birth weight classes.
Animal
February 2025
Research Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany; Chair of Animal Breeding and Genetics, Faculty of Agricultural and Environmental Sciences, University Rostock, Justus-von-Liebig-Weg 7, 18059 Rostock, Germany. Electronic address:
The high mortality rate of suckling piglets in commercial farms is a cause for concern and requires the adoption of innovative breeding and management approaches for effective mitigation. Piglets are particularly vulnerable during the first days of life, which concerns especially neonates with a low birth weight. In this study, neonatal adaptation was analysed regarding genotype and housing conditions following hormonally induced farrowing.
View Article and Find Full Text PDFIs Lactate Clearance Useful in Predicting Cardiopulmonary Resuscitation Outcome and 48-Hour Mortality?
J Coll Physicians Surg Pak
March 2025
Department of Emergency Medicine, School of Medicine, Duzce University, Duzce, Turkiye.
Objective: To investigate the predictive value of lactate clearance (ΔL) in witnessed cardiac arrest patients in the emergency department (ED) at two time points: Cardiopulmonary resuscitation (CPR) outcome and 48-hour mortality.
Study Design: Observational study. Place and Duration of the Study: Department of Emergency Medicine, Duzce University, Duzce, Turkiye, from July 1 to December 31, 2023.
Ultrasound-Guided Fluid Volume Management in Patients With Septic Shock: A Randomized Controlled Trial.
J Trauma Nurs
March 2025
Author Affiliations: Department of Ultrasound Medicine, Xi'an Daxing Hospital, Xi'an City, Shaanxi Province, China (Drs Li, Zhao, Chen, and Yue); Department of Neurosurgery, Xi'an Daxing Hospital, Xi'an City, Shaanxi Province, China (Dr Xu); and Department of Critical Care Medicine, Xi'an Daxing Hospital, Xi'an City, Shaanxi Province, China (Dr Liu).
Background: Ultrasound-guided fluid management is increasingly used in the intensive care unit, yet it's benefits in septic shock remains unknown.
Objective: To evaluate the use of critical care ultrasound for individualized volume management in septic shock patients.
Methods: A single-center, randomized controlled, prospective study was conducted on patients with septic shock admitted to the intensive care unit in Xi'an Daxing Hospital, Xi'an City, China, from September 2022 to December 2023.
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