Background: Online tools can be used by people with dementia and their caregivers to self-identify and track troubling symptoms, such as verbal repetition. We aimed to explore verbal repetition behaviors in people with dementia.
Methods: Participants were recruited via an online resource for people with dementia and their caregivers. Respondents were instructed to complete information about symptoms that are most important to them for tracking over time. In this cross-sectional study, we analyzed data pertaining to individuals with dementia who had at least three symptoms selected for tracking.
Results: Of the 3,573 participants who began a user profile, 1,707 fulfilled criteria for analysis. Verbal repetition was identified as a treatment target in 807 respondents (47.3%). Verbal repetition was more frequent in individuals with mild dementia compared to those with moderate and severe dementia (57.2% vs. 36.0% and 39.9%, p < 0.01) and in those with Alzheimer's disease versus other dementias (65.2% vs. 29.7%, p < 0.001). Repetitive questioning was the most frequent type of verbal repetition (90.5% of individuals with verbal repetition). Verbal repetition was most strongly associated with difficulties operating gadgets/appliances (OR 3.65, 95%CI: 2.82-4.72), lack of interest and/or initiative (3.52: 2.84-4.36), misplacing or losing objects (3.25: 2.64-4.01), and lack of attention and/or concentration (2.62: 2.12-3.26).
Conclusions: Verbal repetition is a common symptom in people at all stages of dementia but is most commonly targeted for monitoring and treatment effects in its mild stage. Much research is required to further elucidate the underlying mechanisms and the effect of different treatment strategies.
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http://dx.doi.org/10.1017/S1041610216002180 | DOI Listing |
Cortex
December 2024
Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Japan.
The applause sign (AS) is a recognized phenomenon observed in progressive supranuclear palsy (PSP) and other neurological conditions where individuals produce over three claps following a request to clap only thrice after a demonstration. In this study, we introduced a novel linguistic phenomenon termed the oral applause sign (OAS) associated with the AS. The OAS is characterized by increased repetition counts of Japanese repetitive onomatopoeic words, such as uttering "pata-pata-pata" instead of the expected "pata-pata.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Hospital de Clínicas, Montevideo, Montevideo, Uruguay.
Background: The prevalence of Dementia in Latin America countries is growing and early presentations of Alzheimer´s Diseases with atypical forms are even more frequently. As the clinical presentation of these variants shows an overlap with other dementia disorders, the differential diagnosis is often challenging. We presented three cases of atypical forms of AD who count with cognitive assessment and pet imaging confirmation in order to being able to discuss the most important points of clinical assessment in every case.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Washington Alzheimer's Disease Research Center, University of Washington School of Medicine, Seattle, WA, USA.
Background: The relationship between Alzheimer's disease (AD) pathology and the associated clinical syndrome a patient presents with remains indeterminate. Cognitively-defined subgroups of AD have revealed distinctions based on relative cognitive impairments, including AD-Language, where challenges in language are substantial, and AD-No Domain, where no relative asymmetries across cognitive domains occur. Pathological features of AD have been associated as the primary neuropathology of the logopenic variant of primary progressive aphasia (lvPPA).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of North Texas Health Science Center, Fort Worth, TX, USA.
Background: Mild cognitive function (MCI) is associated with a declined short-term memory (STM). This study compared STM between adults with MCI and normal cognition assessed by verbal memory vs visuospatial memory.
Methods: Sixteen subjects with MCI and 11 subjects with normal cognition gave their written consent to participate in the study which was approved by the North Texas Regional IRB.
Alzheimers Dement
December 2024
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands.
Background: Verbal fluency, especially semantic fluency, may hold promise to predict clinical progression in the preclinical Alzheimer's disease (AD) stage, where patients show no objective cognitive impairment. We examined verbal fluency trajectories in amyloid-negative and amyloid-positive individuals with subjective cognitive decline (SCD), as well as whether baseline fluency characteristics (total scores and item-level) predicted progression to MCI or AD dementia.
Method: We retrospectively selected data of 471 Dutch individuals with SCD, with at least 1 follow-up fluency assessment, from the Amsterdam Dementia Cohort (Follow-up years = 4.
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