We present a full-polymer respiratory monitoring device suited for application in environments with strong magnetic fields (e.g., during an MRI measurement). The sensor is based on the well-known evanescent field method and consists of a 1 mm plastic optical fiber with a bent region where the cladding is removed and the fiber is coated with poly-dimethylacrylamide (PDMAA). The combination of materials allows for a mass-production of the device by spray-coating and enables integration in disposable medical devices like oxygen masks, which we demonstrate here. We also present results of the application of an autocorrelation-based algorithm for respiratory frequency determination that is relevant for real applications of the device.
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http://dx.doi.org/10.3390/s17030517 | DOI Listing |
Int J Biol Macromol
December 2024
Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, Tianjin 300071, PR China. Electronic address:
For understanding the behavior of the active substance in vivo, the near-infrared (NIR) spectral variations of ovalbumin (OVA) loaded in poly(N, N-dimethyl acrylamide) (PDMAA) hydrogel with temperature were investigated. Analyzing the spectra with improved resolution by continuous wavelet transform (CWT), the absorption variation of the peak at 4851 cm arising from the α-helix of OVA with temperature was studied. The results show that a sharp decrease occurs at a lower temperature in PDMAA hydrogel, indicating that the unfolding of OVA in PDMAA hydrogel is facilitated.
View Article and Find Full Text PDFSoft Matter
September 2024
Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Incorporating associative interactions as the energy dissipation units has been recognized as an effective strategy to develop tough hydrogels. For hydrogen-bond associations, however, it is highly challenging to stabilize them under aqueous conditions. Although affording cooperativity can enhance and stabilize the hydrogen bonds, it usually requires stepwise polymerization to form these cooperative associations between different polymers and networks.
View Article and Find Full Text PDFBiomacromolecules
February 2024
State Key Laboratory of Polymer Materials Engineering, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
The combinational properties with excellent mechanical properties, adhesive performance, hemostatic ability, antibacterial action, and wound healing efficacy are highly desirable for injectable hydrogels' practical applications in hemorrhage control and wound closure, but designing one single hydrogel system integrating with such properties is still difficult. Herein, a simplified yet straightforward strategy is proposed to prepare an injectable and robust poly(,-dimethylacrylamide) (PDMAA)/carboxymethyl chitosan (CMCS) hydrogel induced by tranexamic acid (TXA). TXA not only promotes the rapid generation of free radicals but also introduces multiple hydrogen bonds into the hydrogel network.
View Article and Find Full Text PDFMacromol Rapid Commun
February 2024
Professur für Polymerwerkstoffe, Fachrichtung Materialwissenschaft und Werkstofftechnik, Universität des Saarlandes, Campus, 66123, Saarbrücken, Germany.
Non-monotonous actuation, that is, different kinds of motion in response to a single stimulus, is observed in some natural materials but difficult to implement in synthetic systems. Herein, polymer hydrogel sheets made from polyacrylamide (PAAm) or poly(dimethylacrylamide) (PDMAA) with a cross-linking gradient along the sheet thickness are reported. These are obtained by thermally initiated free radical polymerization using a specially designed Teflon mold with a glass lid.
View Article and Find Full Text PDFACS Appl Mater Interfaces
August 2023
Beijing Engineering Research Center of Orthopedics Implants, Fourth Medical Center of PLA General Hospital, Beijing 100048, China.
Bioactive materials that communicate with bio-tissues via simultaneous chemical and electrical information promise an advanced medical treatment strategy. Rational design of simultaneous chemically and electrically active materials is still challenging. In this study, we develop a bioactive wound healing patch that enables functional recovery of scald skin wounds by integrating electrically and chemically active units at the molecular level.
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