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Genetic susceptibility to optic neuropathy in patients with alcohol use disorder.
J Transl Med
May 2024
Université d'Angers, Unité Mixte de Recherche (UMR) MITOVASC, Institut National de la Santé et de la Recherche Médicale (INSERM U-1083), Centre National de la Recherche Scientifique (CNRS 6015), 49000, Angers, France.
Background: The pathophysiology of toxico-nutritional optic neuropathies remains debated, with no clear understanding of the respective roles played by the direct alcohol toxicity, smoking and the often associated vitamin deficiencies, which are risk factors for optic neuropathy. Our aim was to investigate genetic susceptibility in patients with bilateral infraclinical optic neuropathy associated with chronic alcohol use disorder.
Methods: This retrospective cohort study included 102 visually asymptomatic patients with documented alcohol use disorder from a French reference center.
Bruch Membrane Opening Minimum Rim Width in Neuromyelitis Optica.
J Neuroophthalmol
March 2022
Departments of Ophthalmology (LB, HM); and Neurology (PC), University Hospital of Martinique, Fort de France, France (French West Indies).
Background: Optical coherence tomography (OCT) analyzes the neurodegeneration in neuromyelitis optica (NMO) and multiple sclerosis (MS) and quantifies optical atrophy. The retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness are decreased, and this structural change is correlated with visual function of patients, including contrast vision and visual field deviation. The main objective of this study was to evaluate the Bruch membrane opening minimum rim width (BMO) of the patients with NMO.
View Article and Find Full Text PDF[Cerebrotendinous xanthomatosis: a multicentric retrospective study of 15 adults, clinical and paraclinical typical and atypical aspects].
Rev Neurol (Paris)
May 2015
Service de neurologie, hôpital Gui-de-Chauliac, CHU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier, France. Electronic address:
Introduction: Cerebrotendinous xanthomatosis, a metabolic leukodystrophy with an autosomal recessive inheritance, is secondary to deficiency of sterol 27-hydroxylase, an enzyme involved in cholesterol catabolism. Classical symptoms include clinical or infraclinical xanthomas affecting the skin and tendons, early cataracts, neurological signs and diarrhea. Brain imaging reveals involvement of the dentate nuclei and periventricular white matter hyperintensities.
View Article and Find Full Text PDF[Metabolic neuropathies: overview in 2011].
Rev Neurol (Paris)
December 2012
Centre de référence des maladies neuromusculaires et de la SLA, hôpital de La Timone, AP-HM, 264 rue Saint-Pierre, Marseille cedex 05, France.
Metabolic diseases constitute a frequent etiologic group of axonal and small-fiber neuropathies. Recent works in this field are dominated by diabetic neuropathy (clinical presentation, prognostic factors) because of its prevalence. Vitamin B12 deficiency aroused several studies in 2011.
View Article and Find Full Text PDF[Drug induced neuropathies].
Rev Prat
November 2008
Service de neurologie, hôpital Haut-Lévêque, 33604 Pessac Cedex, France.
The search for a peripheral neuropathy must be systematic when a toxic medicament for the peripheral nervous system is prescribed as well as the search for a drug induced neuropathy is part of the screening of any peripheral neuropathy, but for numerous drugs, the imputability is not strictly demonstrated. A drug induced neuropathy must be differentiated from a neuropathy related to the disease for which the drug was prescribed. It is the case in the course of some cancers and or AIDS.
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