Chiral N,N'-dioxide-Sc(NTf) complex-catalyzed asymmetric bromoamination of chalones with N-bromosuccinimide as both bromine and amide source.

The catalytic asymmetric bromoamination of chalcones with N-bromosuccinimide as both bromine and amide source was realized by using a chiral N,N'-dioxide-Sc(NTf) complex as an efficient catalyst. The corresponding chiral bromoamination products were obtained in high yields with high dr and good ee values (up to 92% yield, 93 : 7 dr and 97% ee) under mild reaction conditions.