AI Article Synopsis

  • * Understanding the damage at a cellular level can enhance early diagnosis and treatment options for keratoconus and other corneal diseases.
  • * This study introduces an optical coherence tomography system capable of high-resolution imaging (0.95 µm), revealing detailed structures in both healthy and keratoconic corneas, including the epithelium and Bowman's membrane.

Article Abstract

Corneal degenerative conditions such as keratoconus (KC) cause progressive damage to the anterior corneal tissue and eventually severely compromise visual acuity. The ability to visualize corneal tissue damage at cellular or sub-cellular level at different stages of development of KC and other corneal diseases, can aid the early diagnostics as well as the development of more effective treatment approaches for various corneal pathologies, including keratoconus. Here, we present the optical design of an optical coherence tomography system that can achieve 0.95 µm axial resolution in biological tissue and provide test results for the system's spatial resolution and sensitivity. Corneal images acquired with this system from healthy and keratoconic human subjects reveal the cellular and sub-cellular structure of the corneal epithelium, as well as the normal and abnormal structure of the Bowman's membrane and the anterior corneal stroma.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330551PMC
http://dx.doi.org/10.1364/BOE.8.000800DOI Listing

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