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Type I interferon and mitochondrial dysfunction are associated with dysregulated cytotoxic CD8+ T cell responses in juvenile systemic lupus erythematosus.
Clin Exp Immunol
December 2024
Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH, GOSH, London, UK.
Juvenile systemic lupus erythematosus (JSLE) is an autoimmune condition which causes significant morbidity in children and young adults and is more severe in its presentation than adult-onset SLE. While many aspects of immune dysfunction have been studied extensively in adult-onset SLE, there is limited and contradictory evidence of how cytotoxic CD8+ T cells contribute to disease pathogenesis and studies exploring cytotoxicity in JSLE are virtually non-existent. Here, we report that CD8+ T cell cytotoxic capacity is reduced in JSLE versus healthy controls, irrespective of treatment or disease activity.
View Article and Find Full Text PDFThe effect of confession evidence on jurors' verdict decisions: A systematic review and meta-analysis.
Law Hum Behav
June 2024
Iowa State University, Department of Psychology.
Objective: Over the past 4 decades, discrepant research findings have emerged in the juror-confession literature, prompting the need for a systematic review and meta-analysis that assesses the effect of confession evidence (coerced or noncoerced) on conviction rates and the efficacy of trial safeguards.
Hypotheses: We did not predict any directional hypotheses. Some studies show increased convictions when a confession is present (vs.
The impact of misinformation presented during jury deliberation on juror memory and decision-making.
Front Psychol
January 2024
School of Psychological Sciences, University of Newcastle, Callaghan, NSW, Australia.
When deliberating, jurors may introduce misinformation that may influence other jurors' memory and decision-making. In two studies, we explored the impact of misinformation exposure during jury deliberation. Participants in both studies read a transcript of an alleged sexual assault.
View Article and Find Full Text PDFCreating successful patient partnerships in healthcare education to potentially improve students' understanding of patient-centered care.
J Prof Nurs
December 2023
Saskatchewan Polytechnic, Regina Campus, Treaty 4 Territory and Homelands of the Metis, People, 4635 Wascana Pky, PO Box 556, Regina, SK S4P 3A3, Canada.
Healthcare systems around the world are constantly evolving to meet the diverse needs of the people they serve. Patient-centered care is recognized as a crucial element in providing high-quality care (Najafizada et al., 2021; Anderson & Gagliardi, 2021; Kwame & Petrucka, 2021).
View Article and Find Full Text PDFEfficacy and safety of ciclosporin versus methotrexate in the treatment of severe atopic dermatitis in children and young people (TREAT): a multicentre parallel group assessor-blinded clinical trial.
Br J Dermatol
November 2023
Paediatric Dermatology, Children's Health Ireland at Crumlin, Dublin, Ireland.
Article Synopsis
- A study compared the safety and effectiveness of ciclosporin (CyA) and methotrexate (MTX) in treating severe atopic dermatitis (AD) in children and young people aged 2-16 who didn't respond to topical treatments.
- Cyclists showed more significant improvement at the 12-week mark, with more patients achieving at least a 50% improvement in their AD scores compared to those on MTX.
- However, by the 60-week follow-up, MTX demonstrated better long-term outcomes, indicating its potential superiority beyond the initial treatment period.
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