Distribution-aware estimation of the minimum achievable uncertainty in diffusion-tensor imaging (DTI).

Diffusion tensor imaging (DTI) provides exquisite sensitivity to structural and microstructural characteristics of brain tissue, and is routinely employed in advanced neuroimaging applications. DTI is commonly performed using intrinsically noisy echo-planar imaging techniques and poses high demands both on scanner performance and on in-scanner subject time, which in turn is directly related to the number of diffusion-weighting direction one requires. While DTI-derived indices such as fractional anisotropy (FA), diffusion tensor trace and anisotropy mode have proven extremely useful in characterizing disease-related aberrations, their estimation is commonly performed using fitting routines that do not properly take into account MRI noise distribution. In this paper, we present a distribution-aware maximum likelihood tensor estimation framework which also allows, for the first time, separate local noise estimation in both diffusion weighted and reference images. We validate our framework using multiple water phantom diffusion weighted acquisitions, and demonstrate its feasibility in human data. We then employ our framework within Monte Carlo simulations to show how the minimum achievable uncertainty attainable in DTI depends on signal-to-noise ratio (SNR) and number of diffusion gradient directions, demonstrating that these dependencies could be recast into simple power laws which may serve as guidelines for application-specific DTI protocol design.