This study proposes a Cross-Correlated Delay Shift (CCDS) supervised learning rule to train neurons with associated spatiotemporal patterns to classify spike patterns. The objective of this study was to evaluate the feasibility of using the CCDS rule to automate the detection of interictal spikes in electroencephalogram (EEG) data on patients with epilepsy. Encoding is the initial yet essential step for spiking neurons to process EEG patterns. A new encoding method is utilized to convert the EEG signal into spike patterns. The simulation results show that the proposed algorithm identified 69 spikes out of 82 spikes, or 84% detection rate, which is quite high considering the subtleties of interictal spikes and the tediousness of monitoring long EEG records. This CCDS rule is also benchmarked by ReSuMe on the same task.
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http://dx.doi.org/10.1109/EMBC.2016.7590821 | DOI Listing |
J Neurophysiol
January 2025
Department of Integrative Physiology, University of Colorado Boulder.
Our purpose was to compare the influence of the spectral content of motor unit recordings on the calculation of electromechanical delay and on the prediction of force fluctuations from measures of the variability in discharge times and neural drive during steady isometric contractions with the first dorsal interosseus muscle. Participants ( = 42; 60 ± 13 yrs) performed contractions at 5% and 20% MVC. After satisfying inclusion criteria, high-density surface EMG recordings from a subset of 23 participants were decomposed into the discharge times of 530 motor units.
View Article and Find Full Text PDFJ Biomol NMR
August 2024
Biological and Environmental Science & Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
The dynamics of the backbone and side-chains of protein are routinely studied by interpreting experimentally determined N spin relaxation rates. R(N), the longitudinal relaxation rate, reports on fast motions and encodes, together with the transverse relaxation R, structural information about the shape of the molecule and the orientation of the amide bond vectors in the internal diffusion frame. Determining error-free N longitudinal relaxation rates remains a challenge for small, disordered, and medium-sized proteins.
View Article and Find Full Text PDFJ Appl Physiol (1985)
November 2022
School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Queensland, Australia.
The integration of electromyography (EMG) and ultrasound imaging has provided important information about the mechanisms of muscle activation and contraction. Unfortunately, conventional bipolar EMG does not allow an accurate assessment of the interplay between the neural drive received by muscles, changes in fascicle length and torque. We aimed to assess the relationship between modulations in tibialis anterior muscle (TA) motor unit (MU) discharge, fascicle length, and dorsiflexion torque using ultrasound-transparent high-density EMG electrodes.
View Article and Find Full Text PDFJ Endocr Soc
September 2021
Section Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Objective: To investigate the relationship between LH and testosterone (T), which characteristics associate with the strength of this relationship, and their interrelationships with GH, TSH, cortisol, and ACTH.
Design: Hormones were measured in serum samples collected every 10 minutes during 24 hours from 20 healthy men, comprising 10 offspring of long-lived families and 10 control subjects, with a mean (SD) age of 65.6 (5.
J Magn Reson
September 2021
Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA. Electronic address:
A simple NMR experiment for the measurement of transverse relaxation rates of degenerate H spins in CH methyl groups of deuterated proteins, is described. The experiment relies on the use of acute-angle H radio-frequency pulses, whereby a series of methyl H R decays is acquired with different values of the H pulse flip-angle, which modulates the relative contributions of the slow- and fast-relaxing components of H magnetization during the relaxation delay. These are subsequently analyzed simultaneously to extract the transverse relaxation rates of both components (R and R), along with the rate of cross-relaxation between these components, δ.
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