Most of the de novo BRCA1/2 mutations have been identified in patients with early-onset breast cancer and without family history of the disease. The identification of these alterations could play a prominent role in the prevention and treatment strategies and may influence clinical management of patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331191 | PMC |
| http://dx.doi.org/10.1002/ccr3.718 | DOI Listing |
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