AI Article Synopsis

  • This study investigates the therapeutic potential of traditional medicinal fungi extracts for treating melanoma and triple-negative breast cancer, focusing on their anti-inflammatory, anticancer, and anti-metastatic properties.
  • The research utilized MDA-MB 231 and B16-F10 cell lines to measure cell viability, wound healing, and cytokine release under pro-inflammatory conditions, demonstrating the fungi extracts' ability to reduce IL-8, IL-6, MMP-2, and MMP-9 levels.
  • Results showed that these extracts significantly decreased cancer cell viability and migration in a time- and concentration-dependent manner, suggesting their potential as a treatment option for these aggressive cancers.

Article Abstract

Among the most important traditional medicinal fungi, has been used as a therapeutic agent for the treatment of numerous diseases, including cancer, in Oriental countries. The aim of this study is to investigate the anti-inflammatory, anticancer and anti-metastatic activities of extracts in melanoma and triple-negative breast cancer cells. extracts were prepared by using common organic solvents; MDA-MB 231 and B16-F10 cell lines were adopted as cellular models for triple-negative breast cancer and melanoma and characterized for cell viability, wound-healing assay and measurement of cytokines secreted by cancer cells under pro-inflammatory conditions (incubation with lipopolysaccharide, LPS) and pretreatment with extract at different concentrations. Our study demonstrates, for the first time, how extracts can significantly inhibit the release of IL-8, IL-6, MMP-2 and MMP-9 in cancer cells under pro-inflammatory condition. Interestingly, extracts significantly also decrease the viability of both cancer cells in a time- and concentration-dependent manner, with abilities to reduce cell migration over time, which is correlated with a lower release of matrix metalloproteases. Taken together, these results indicate the possible use of extract for the therapeutic management of melanoma and human triple-negative breast cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372873PMC
http://dx.doi.org/10.3390/nu9030210DOI Listing

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