Molecular amplification in a dithioacetal-based dynamic library is described for the first time. The homatropine induced selection, amplification, and isolation of one cyclophane host demonstrates the utility of dithioacetal exchange for preparing responsive dynamic libraries. Nuclear magnetic resonance and isothermal titration calorimetry analysis suggest that the amplified macrocycle forms a 1:1 complex with the template. This is the first report about a host/guest system involving a dithioacetal cyclophane.
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Host Amplification in a Dithioacetal-Based Dynamic Covalent Library.
Org Lett
March 2017
Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario (UNR-CONICET), Ocampo y Esmeralda, Rosario (2000), Argentina.
Molecular amplification in a dithioacetal-based dynamic library is described for the first time. The homatropine induced selection, amplification, and isolation of one cyclophane host demonstrates the utility of dithioacetal exchange for preparing responsive dynamic libraries. Nuclear magnetic resonance and isothermal titration calorimetry analysis suggest that the amplified macrocycle forms a 1:1 complex with the template.
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