Boronic acid-modified alginate enables direct formation of injectable, self-healing and multistimuli-responsive hydrogels.

Chem Commun (Camb)

Institute of Organic Chemistry, University of Regensburg, Universitaetsstr. 31, 93040 Regensburg, Germany. and IQAC-CSIC, Jordi Girona 18-26, Barcelona 08034, Spain.

Published: March 2017

One-step functionalization of alginate with boronic acid groups allowed spontaneous formation of biocompatible hydrogels under basic conditions without additional complementary molecules or crosslinking agents. The dynamic nature of boronate ester bonds formed with vicinal diols present on alginate pyranose rings provided remarkable self-healing, injectable and multi-stimuli responsive properties to the material.

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http://dx.doi.org/10.1039/c7cc00765eDOI Listing

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