Background: Both inflammation and immunity are associated with the development of malignancy. The lymphocyte-to-monocyte ratio (LMR) has been confirmed as a prognostic factor for several malignant diseases. The purpose of our study was to analyze prognostic significance of preoperative LMR in hepatitis B virus (HBV)-related hepatocellular carcinoma after curative resection.
Patients And Methods: A total of 253 patients with primary HBV-positive hepatocellular carcinoma who underwent a curative operation were enrolled in this retrospective study. The relationship between preoperative LMR and survival outcomes was analyzed through Kaplan-Meier curves and multivariate Cox regression analyses.
Results: Patients with a high LMR had a significantly higher mean overall survival than those with a low LMR (67 months vs 55 months, =0.023), and high LMR remained significant for longer survival in the multivariate analysis (hazard ratio, 0.147; 95% confidence interval [CI]: 0.085-0.253; =0.021). Furthermore, patients with a high LMR also had a higher median recurrence-free survival than those with a low LMR in univariate analyses (60 months vs 48 months, =0.026) and multivariate analyses (hazard ratio, 0.317; 95% CI: 0.042-1.023; =0.032). However, the survival benefit was limited to patients with advanced cancer.
Conclusion: LMR was confirmed as an independent prognostic biomarker for primary HBV-positive hepatocellular carcinoma after curative resection.
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| http://dx.doi.org/10.2147/OTT.S110411 | DOI Listing |
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