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Clozapine-Induced Myocarditis in a Young Man with Refractory Schizophrenia: Case Report of a Rare Adverse Event and Review of the Literature.
Am J Case Rep
July 2022
Department of Internal Medicine, Metropolitan Hospital Center, New York City Health + Hospitals, New York City, USA.
BACKGROUND Myocarditis is cardiac muscle inflammation caused by infectious or noninfectious agents. Rarely, clozapine, an atypical antipsychotic drug used to treat resistant schizophrenia, has been reported to cause myocarditis, as we report in this case. CASE REPORT A 29-year-old man, who was known to have schizophrenia and was on olanzapine therapy, presented in our Emergency Department with active psychosis, and was subsequently admitted to the psychiatric ward for refractory schizophrenia.
View Article and Find Full Text PDFClozapine-Induced Pericardial Effusion Presenting with Persistent Tachycardia.
Case Rep Med
August 2021
Internal Medicine-Metropolitan Hospital Center, 1901 1st Avenue, New York, NY, 10029, USA.
Clozapine is an atypical antipsychotic used in refractory schizophrenia and depression. Its use is often complicated by its vast side-effect profile including cardiovascular reactions, agranulocytosis, and seizures. Specifically, the cardiac complications of clozapine have been shown to predominantly cause myocarditis and pericarditis.
View Article and Find Full Text PDFContinuing clozapine treatment after a diagnosis of cardiomyopathy.
Ir J Psychol Med
September 2021
Medicines Management Team, NHS Lothian, Edinburgh, UK.
A patient in a medium secure psychiatric unit with a 19-year history of treatment-resistant schizophrenia and violence whose mental illness only responded to clozapine, was noted to have a sustained tachycardia. Echocardiography revealed mild biventricular cardiomyopathy. The patient was not significantly affected by this.
View Article and Find Full Text PDF"My Heart Said It's Swollen": A Rare Case of Clozapine-Induced Myocarditis in a Schizophrenic Patient.
Cureus
May 2021
Cardiology, Northwell Health, Manhasset, USA.
Clozapine is a Food and Drug Administration-approved, second-generation antipsychotic used to treat treatment-resistant schizophrenia. Known for its benefits in reducing extrapyramidal symptoms typically seen with antipsychotics, this drug carries a risk of agranulocytosis and, to a lesser-known extent, myocarditis. A 49-year-old patient, who was initially admitted to psychiatry with a primary diagnosis of schizophrenia, was started on clozapine.
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