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Concave Magnetic-Responsive Hydrogel Discs for Enhanced Bioassays.
Biosensors (Basel)
December 2024
School of Engineering, University of Guelph, Guelph, ON N1G 2W1, Canada.
Receptor-based biosensors often suffer from slow analyte diffusion, leading to extended assay times. Moreover, existing methods to enhance diffusion can be complex and costly. In response to this challenge, we presented a rapid and cost-effective technique for fabricating concave magnetic-responsive hydrogel discs (CMDs) by straightforward pipetting directly onto microscope glass slides.
View Article and Find Full Text PDFAdvanced transdermal drug delivery system: A comprehensive review of microneedle technologies, novel designs, diverse applications, and critical challenges.
Int J Pharm
December 2024
Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA 30341, USA.
Transdermal drug delivery presents numerous advantages over conventional administration routes, including non-invasiveness, enhanced patient adherence, circumvention of hepatic first-pass metabolism, self-administration capabilities, controlled release, and increased bioavailability. Nevertheless, the barrier function of stratum corneum limits this strategy to molecules possessing requisite physicochemical attributes. To expand the field of transdermal delivery, researchers have pioneered physical enhancement techniques, with micron-sized needles emerging as a particularly promising platform for the transdermal and intradermal delivery of therapeutic agents across a spectrum of molecular sizes.
View Article and Find Full Text PDFMacrobenthic assemblages of anthropogenically active subtidal zones contiguous to a marine protected area: a 9-year revisit.
Environ Sci Pollut Res Int
December 2024
CSIR-National Institute of Oceanography, Regional Centre, Andheri (West), Mumbai, 400 053, India.
Traditional taxonomical methods, an appropriate Benthic Biotic Index incorporating the Taxonomical Sufficiency concept and Biological Traits Analyses, were applied concurrently to evaluate the long-term variations in the benthic ecology of subtidal zones of a Marine-Protected Area subjected to prevalent oil and gas industrial activities. Our evaluation spanned two comparable surveys conducted 9 years apart (2010 vs. 2019).
View Article and Find Full Text PDFThermodynamics of Electrochemical Marine Inorganic Carbon Removal.
Environ Sci Technol
December 2024
Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
In recent years, marine carbon removal technologies have gained attention as a means of reducing greenhouse gas concentrations. One family of these technologies is electrochemical systems, which employ Faradaic reactions to drive alkalinity-swings and enable dissolved inorganic carbon (DIC) removal as gaseous CO or as solid minerals. In this work, we develop a thermodynamic framework to estimate upper bounds on performance for Faradaic DIC removal systems.
View Article and Find Full Text PDFHistorical soil compaction impairs biogeochemical cycling in restored tidal marshes through reduced groundwater dynamics.
Sci Total Environ
December 2024
ECOSPHERE, Department of Biology, University of Antwerp, Wilrijk, Belgium.
Tidal marshes are often restored on compact agricultural soil that limits tidally induced groundwater dynamics and soil aeration after restoration. We hypothesized that impaired soil aeration affects biogeochemical cycling and leads to altered porewater nutrient concentrations in restored tidal marshes. We studied soil hydraulic properties, groundwater dynamics and porewater nutrient concentrations (nitrogen, phosphorus and dissolved silica) over the course of one year in a natural and a restored freshwater tidal marsh in the Scheldt estuary, Belgium.
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