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Usefulness of a novel density measurement drill for evaluating cancellous bone density: correlation between CT value and drilling torque value in bovine ribs.
Int J Implant Dent
January 2025
Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima City, 734-8553, Hiroshima, Japan.
Purpose: The study aimed to examine the usefulness of a novel density measurement drill for evaluating cancellous bone density by examining the correlation between computed tomography (CT)-based Misch bone density classification and drilling torque value.
Methods: Bovine ribs were used as the drilling sites for implant placement. Multidetector CT (MDCT) was performed after contrast materials were attached to the drilling sites.
Deprotonation-Constructed Instant Gelation Coating for Staphylococcus Disinfection and Preservation of Fresh Food in Multiple Scenarios.
Small
January 2025
School of Materials Science & Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Yaguan Road 135#, Tianjin, 300072, China.
The ancient proverb "disease enters through the mouth" elucidates the connection between food and pathogens, underscoring the pivotal role of food preservation in preventing foodborne diseases. Drawing inspiration from ancient food preservation techniques such as waxing and the use of spices, a novel approach combining the deprotonation-induced solid-liquid phase separation of natural polymer solutions with the solubilization of plant-derived antibacterial compounds has been developed. The "two-step soaking" construction strategy enables the creation of biodegradable and adaptable for hydrogel coatings with micro-scale thickness.
View Article and Find Full Text PDFNanotherapies Based on ROS Regulation in Oral Diseases.
Adv Sci (Weinh)
January 2025
Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Oral diseases rank among the most prevalent clinical conditions globally, typically involving detrimental factors such as infection, inflammation, and injury in their occurrence, development, and outcomes. The concentration of reactive oxygen species (ROS) within cells has been demonstrated as a pivotal player in modulating these intricate pathological processes, exerting significant roles in restoring oral functionality and maintaining tissue structural integrity. Due to their enzyme-like catalytic properties, unique composition, and intelligent design, ROS-based nanomaterials have garnered considerable attention in oral nanomedicine.
View Article and Find Full Text PDFT2-low severe asthma clinical spectrum and impact: The Greek PHOLLOW cross-sectional study.
Clin Transl Allergy
February 2025
1st University Department of Respiratory Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Background: Data on type 2 (T2)-low severe asthma (SA) frequency is scarce, resulting in an undefined unmet therapeutic need in this patient population. Our objective was to assess the frequency and characterize the profile and burden of T2-low SA in Greece.
Methods: PHOLLOW was a cross-sectional study of adult SA patients.
Assessment of Potential Drug-Drug Interactions for Novel Oral Melanocortin-1 Receptor Agonist Dersimelagon.
Pharmacol Res Perspect
February 2025
CareCeutics LLC, Berwyn, Pennsylvania, USA.
Dersimelagon is a novel investigational orally administered selective agonist of the melanocortin-1 receptor. The drug-drug interaction (DDI) potential of dersimelagon was investigated in both nonclinical (in vitro) and clinical studies. The in vitro inhibition of CYP/UGT isoforms and efflux/uptake transporters by dersimelagon was assessed.
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