Research suggests that an overgeneral autobiographical memory style (i.e., retrieval of general memories when instructed to retrieve a specific episodic memory) represents a vulnerability marker for depression. Although adolescence is a period of high risk for the emergence of depression, little research has investigated the associations among overgeneral memory, psychopathology, and risk factors longitudinally in a community sample in this age group. We, therefore, investigated overgeneral memory, psychopathology (depression and anxiety), and rumination (an established risk factor for psychopathology) longitudinally in 269 typically-developing youth (125 females, 144 males) across 3 annual assessment points. We sought to determine whether 1) overgeneral memory would predict psychopathology across the entire sample, and 2) whether associations would vary as a function of longitudinal rumination growth. Across the entire sample, overgeneral memory did not predict psychopathology. For youth who reported elevated, and increasing, patterns of rumination over time, transient relationships between overgeneral memory and subsequent increases in anxiety were found. We conclude that overgeneral memory may represent a vulnerability marker for adverse psychological outcomes only for youth at risk for psychopathology.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1007/s10802-017-0278-5 | DOI Listing |
J Affect Disord
January 2025
Department of Psychiatry, University of Oxford, Warneford Ln, Headington, Oxford OX3 7JX, United Kingdom; Oxford Health NHS Foundation Trust, Warneford Ln, Headington, Oxford OX3 7JX, United Kingdom. Electronic address:
Background: The renin angiotensin system (RAS) is implicated in various cognitive processes relevant to anxiety. However, the role of the RAS in pattern separation, a hippocampal memory mechanism that enables discrete encoding of similar stimuli, is unclear. Given the proposed role of this mechanism in overgeneralization and the maintenance of anxiety, we explored the influence of the RAS on mnemonic discrimination i.
View Article and Find Full Text PDFBiol Psychiatry Glob Open Sci
March 2025
Department of Psychiatry, Division of Systems Neuroscience, Columbia University, New York State Psychiatric Institute, New York, New York.
Background: Impairments in behavioral pattern separation (BPS)-the ability to distinguish between similar contexts or experiences-contribute to memory interference and overgeneralization seen in many neuropsychiatric conditions, including depression, anxiety, posttraumatic stress disorder, dementia, and age-related cognitive decline. Although BPS relies on the dentate gyrus and is sensitive to changes in adult hippocampal neurogenesis, its significance as a pharmacological target has not been tested.
Methods: In this study, we applied a human neural stem cell high-throughput screening cascade to identify compounds that increase human neurogenesis.
J Trauma Stress
January 2025
Department of Clinical, Educational, and Health Psychology, University College London, London, UK.
The processing of positive memories technique (PPMT) entails detailed narration and processing of specific positive autobiographical memories (AM) and has shown promise in improving posttraumatic stress disorder (PTSD) symptoms. We examined whether participants receiving PPMT reported decreases in PTSD and depressive symptom severity, negative affect levels/reactivity, posttrauma cognitions, and positive emotion dysregulation, as well as increases in positive affect levels/reactivity and the number of retrieved positive AMs across four PPMT sessions. Individuals (N = 70) recruited from the community completed surveys at baseline (pre-PPMT), each PPMT session, and after completing all four PPMT sessions.
View Article and Find Full Text PDFCogn Affect Behav Neurosci
January 2025
Center for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
Post-traumatic stress and major depressive disorders are associated with "overgeneral" autobiographical memory, or impaired recall of specific life events. Interpersonal trauma exposure, a risk factor for both conditions, may influence how symptomatic trauma-exposed (TE) individuals segment everyday events. The ability to parse experience into units (event segmentation) supports memory.
View Article and Find Full Text PDFJ Neuropsychol
December 2024
Centre Memoire Ressource et Recherche (CMRR), Departement de Neurologie, CHU de Nantes, Nantes, France.
Autobiographical memory is diminished in patients with behavioural variant of frontotemporal dementia (bvFTD), and research has focused on the hampered ability of patients to retrieve specific memories. In this study, we implemented a methodology seeking to provide a qualitative analysis of autobiographical specificity. We invited patients with bvFTD and control participants to retrieve autobiographical memories and we distinguished between specific, categoric, extended and semantic autobiographical retrieval.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!