A novel I-promoted direct conversion of arylacetic acids into aryl carboxylic acids under metal-free conditions has been described. This remarkable transformation involves decarboxylation followed by an oxidation reaction enabled just by using DMSO as the solvent as well as an oxidant. Notably, aryl carboxylic acids are isolated by simple filtration technique and obtained in good to excellent yields. This protocol is free from chromatographic purification, which makes it applicable for large-scale synthesis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.joc.7b00242 | DOI Listing |
Publication Analysis
Top Keywords
aryl carboxylic
12
carboxylic acids
12
arylacetic acids
8
acids
5
metal-free dehomologative
4
dehomologative oxidation
4
oxidation arylacetic
4
acids synthesis
4
synthesis aryl
4
acids novel
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!