Discipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, 4000, South Africa.
Published: August 2017
AI Article Synopsis
Article Abstract
The detrimental effects of drug abuse are apparently not limited to individuals but may also impact the vulnerability of their progenies to develop addictive behaviours. Epigenetic signatures, early life experience and environmental factors, converge to influence gene expression patterns in addiction phenotypes and consequently may serve as mediators of behavioural trait transmission between generations. The majority of studies investigating the role of epigenetics in addiction do not consider the influence of social interactions. This shortcoming in current experimental approaches necessitates developing social models that reflect the addictive behaviour in a free-living social environment. Furthermore, this review also reports on the advancement of interventions for drug addiction and takes into account the emerging roles of histone deacetylase (HDAC) inhibitors in the etiology of drug addiction and that HDAC may be a potential therapeutic target at nucleosomal level to improve treatment outcomes.
Material stocks of infrastructure, buildings, and machinery are the biophysical basis of production and consumption. They are a crucial lever for resource efficiency and a sustainable circular economy. While material stock research has proliferated over the last years, most studies investigated specific materials or end-uses, usually not embedded into an economy-wide perspective.
The rollout of electric vehicles and photovoltaic panels is essential to mitigate climate change. However, they depend on technology-critical elements (TCEs), which can be harmful to human health and whose use is rapidly expanding, while recycling is lacking. While mining has received substantial attention, in-use dissipation in urban areas has so far not been assessed, for example, corrosion and abrasion of vehicle components and weather-related effects affecting thin-film photovoltaic panels.
Department of Environmental Health Sciences, College of Integrated Health Sciences, University at Albany, State University of New York, Rensselaer, New York 12144, United States.
The health impact of electric vehicles (EVs) is complex and multifaceted, encompassing reductions in air pollutants, improvements in road safety, and implications for social equity. However, existing studies often provide fragmented insights, lacking a unified framework to comprehensively assess these public health implications. This paper develops a comprehensive framework to summarize the health outcomes of EVs in urban areas, where the health impacts are more pronounced due to higher levels of traffic congestion and air pollution.
Regular physical activity can prevent various physical and mental illnesses or improve their prognosis. However, only about half of the German population meets the WHO recommendations for physical activity. The aim of this study was to identify factors that influence engagement in regular exercise and could help increase physical activity levels in the general population.
Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes 3900, Ribeirão Preto, São Paulo,14049-900, Brazil; Behavioural Neurosciences Institute (INeC), Av. Bandeirantes 3900, Ribeirão Preto, 14040-900, São Paulo, Brazil. Electronic address:
Pain is a multifactorial debilitating condition associated with some psychiatric comorbidities such as generalized anxiety and depression. Concerning pharmacological treatment, which is often inefficient or associated with intense side effects, the physical and social context may be fundamental for patient's health improvement. In this sense, we sought to assess the impact of an enriched environment (EE) on neuropathic pain (NP) and depression comorbid.
