We discuss here an uncommon condition of neurogenic hypotension in the context of immunoglobulin light chain (amyloid light-chain) amyloidosis. The most serious feature was autonomic nervous system impairment, mainly characterized by severe refractory orthostatic hypotension, which became progressively invalidating, forcing the patient to bed. Moreover, since the systemic involvement of the disease, the patient presented also diarrhea, dysphagia, asthenia, peripheral edema because of gastrointestinal, and kidney dysfunction. Eventually, the massive myocardial depression and infiltration led to a fatal outcome.
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http://dx.doi.org/10.4103/1735-1995.193508 | DOI Listing |
J Phys Condens Matter
January 2025
Biozentrum, University of Basel, Spitalstrasse 41, Basel, Basel-Stadt, 4056, SWITZERLAND.
Activity and autonomous motion are fundamental aspects of many living and engineering systems. Here, the scale of biological agents covers a wide range, from nanomotors, cytoskeleton, and cells, to insects, fish, birds, and people. Inspired by biological active systems, various types of autonomous synthetic nano- and micromachines have been designed, which provide the basis for multifunctional, highly responsive, intelligent active materials.
View Article and Find Full Text PDFAm J Hum Genet
January 2025
Division of Biostatistics and Health Data Science, University of Minnesota, Minneapolis, MN, USA. Electronic address:
Alzheimer disease (AD) is a complex and progressive neurodegenerative disorder that accounts for the majority of individuals with dementia. Here, we aim to identify causal plasma proteins for AD, shedding light on the etiology of AD. We utilized the latest large-scale plasma proteomic data from the UK Biobank Pharma Proteomics Project (UKB-PPP) and AD genome-wide association study (GWAS) summary data from the International Genomics of Alzheimer's Project (IGAP).
View Article and Find Full Text PDFDiabetol Metab Syndr
January 2025
First Central Clinical Medical Institute, Tianjin Medical University, Tianjin, China.
Background: To identify the relationship between BMI or lipid metabolism and diabetic neuropathy using a Mendelian randomization (MR) study.
Methods: Body constitution-related phenotypes, namely BMI (kg/m), total cholesterol (TC), and triglyceride (TG), were investigated in this study. Despite the disparate origins of these data, all were accessible through the IEU OPEN GWAS database ( https://gwas.
Infect Drug Resist
December 2024
Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.
Introduction: Tuberculosis is prevalent in high-burden countries. However, spinal multi-drug resistant tuberculosis (MDR-TB) in patients with normal immune function is a disease that is prone to misdiagnosis and even delayed diagnosis. Recently, we successfully treated one such patient.
View Article and Find Full Text PDFNeurology
January 2025
Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Language plays an important role in ensuring gender inclusivity within neurology. Despite progress in language inclusivity, such as the emergence of explicit pronouns, more remains to be done. Historically, sex and gender have been used interchangeably, but they are, in fact, distinct concepts.
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