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Impact on seafarers of extreme events: A case study arising out of the situation in Ukraine.
Int Marit Health
October 2024
World Maritime University, Malmö, Sweden.
Background: Maritime transportation is the lifeblood of the world's economy. However, seafarers are exposed to isolated, confined and particularly extreme environments. Maritime operations in the face of geopolitical conflicts profoundly impact seafarers' mental health, well-being and safety.
View Article and Find Full Text PDFCombining full-length gene assay and SpliceAI to interpret the splicing impact of all possible SPINK1 coding variants.
Hum Genomics
February 2024
Univ Brest, Inserm, EFS, UMR 1078, GGB, F-29200 Brest, France.
Background: Single-nucleotide variants (SNVs) within gene coding sequences can significantly impact pre-mRNA splicing, bearing profound implications for pathogenic mechanisms and precision medicine. In this study, we aim to harness the well-established full-length gene splicing assay (FLGSA) in conjunction with SpliceAI to prospectively interpret the splicing effects of all potential coding SNVs within the four-exon SPINK1 gene, a gene associated with chronic pancreatitis.
Results: Our study began with a retrospective analysis of 27 SPINK1 coding SNVs previously assessed using FLGSA, proceeded with a prospective analysis of 35 new FLGSA-tested SPINK1 coding SNVs, followed by data extrapolation, and ended with further validation.
Preferences in AI algorithms: The need for relevant risk attitudes in automated decisions under uncertainties.
Risk Anal
October 2024
Department of Management Science and Engineering, Stanford University, Stanford, California, USA.
Artificial intelligence (AI) has the potential to improve life and reduce risks by providing large amounts of information embedded in big databases and by suggesting or implementing automated decisions under uncertainties. Yet, in the design of a prescriptive AI algorithm, some problems may occur, first and clearly, if the AI information is wrong or incomplete. But the main point of this article is that under uncertainties, the decision algorithm, rational or not, includes, in one way or another, a risk attitude in addition to deterministic preferences.
View Article and Find Full Text PDFAdapted sailing teaching methodology using vsail-trainer simulator as rehabilitation therapy. A feasibility study.
J Spinal Cord Med
November 2024
Sport Sciences Research Centre, Rey Juan Carlos University, Fuenlabrada (Madrid), Spain.
Sailing is a sport that can help in the rehabilitation of Spinal Cord Injury (SCI) patients and improve their quality of life. Teaching methodology in sailing has always been considered as complex, due to the great amount of uncertainty that this sport has. To design a protocol for teaching adapted sailing in a simulated situation for people with SCI and to know the effect of the teaching protocol on learning, effort perception and heart rate.
View Article and Find Full Text PDFSailing through the southern seas of air-sea CO flux uncertainty.
Philos Trans A Math Phys Eng Sci
June 2023
Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA.
The Southern Ocean is among the largest contemporary sinks of atmospheric carbon dioxide on our planet; however, remoteness, harsh weather and other circumstances have led to an undersampling of the ocean basin, compared with its northern hemispheric counterparts. While novel data interpolation methods can in part compensate for such data sparsity, recent studies raised awareness that we have hit a wall of unavoidable uncertainties in air-sea [Formula: see text] flux reconstructions. Here, we present results from autonomous observing campaigns using a novel platform to observe remote ocean regions: sailboats.
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