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| http://dx.doi.org/10.21037/atm.2017.01.65 | DOI Listing |
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In the heart, cell-matrix and cell-cell adhesions reorganize in response to increased cardiac demand and growth to promote cardiomyocyte maturation. Vinculin, a mechanosensitive adaptor protein, links filamentous actin to cell-matrix and cell-cell adhesions and is thus positioned to regulate adhesion reorganization. However, how the two adhesion systems are coordinated in the heart, and the role of vinculin in this process is poorly understood.
View Article and Find Full Text PDFNanotopography promotes cardiogenesis of pluripotent stem cell-derived embryoid bodies through focal adhesion kinase signaling.
Biochem Biophys Res Commun
November 2024
Department of Cardiology, Cardiovascular Center, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, South Korea. Electronic address:
Controlling the microenvironment surrounding the pluripotent stem cells (PSCs) is a pivotal strategy for regulating cellular differentiation. Surface nanotopography is one of the key factors influencing the lineage-specific differentiation of PSCs. However, much of the underlying mechanism remains unknown.
View Article and Find Full Text PDFDysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations.
bioRxiv
December 2024
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC and Raleigh, NC, USA.
Somatic activating mutations in are common drivers of vascular and lymphatic malformations. Despite common biophysical signatures of tissues susceptible to lesion formation, including compliant extracellular matrix and low rates of perfusion, lesions vary in clinical presentation from localized cystic dilatation to diffuse and infiltrative vascular dysplasia. The mechanisms driving the differences in disease severity and variability in clinical presentation and the role of the biophysical microenvironment in potentiating progression are poorly understood.
View Article and Find Full Text PDFFocal Adhesion's Role in Cardiomyocytes Function: From Cardiomyogenesis to Mechanotransduction.
Cells
April 2024
Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.
Article Synopsis
- - Mechanotransduction is the process by which cells detect mechanical stimuli and convert them into biochemical signals, with focal adhesions (FAs) being crucial for this function as they connect the cell's internal structure to the extracellular environment.
- - FAs play significant roles in various cellular activities such as adhesion, growth, and migration, and their signaling molecules like FAK, integrins, and vinculin are important for heart cell development and function.
- - The review discusses how cardiomyocytes respond to the stiffness of their extracellular matrix via signaling pathways influenced by FAs, highlighting their importance in cardiac function and adaptation to mechanical forces.
Identification of a hub gene VCL for atherosclerotic plaques and discovery of potential therapeutic targets by molecular docking.
BMC Med Genomics
January 2024
Department of Vascular Surgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Background: Atherosclerosis (AS) is a pathology factor for cardiovascular diseases and instability of atherosclerotic plaques contributes to acute coronary events. This study identified a hub gene VCL for atherosclerotic plaques and discovered its potential therapeutic targets for atherosclerotic plaques.
Methods: Differential expressed genes (DEGs) were screened between unstable and stable plaques from GSE120521 dataset and then used for construction of a protein-protein interactions (PPI) network.
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