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Sequential Double "Clicks" toward Structurally Well-Defined Heterogeneous -Glycoclusters: The Importance of Cluster Heterogeneity on Pattern Recognition In Vivo. | LitMetric
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Sequential Double "Clicks" toward Structurally Well-Defined Heterogeneous -Glycoclusters: The Importance of Cluster Heterogeneity on Pattern Recognition In Vivo.

Liliya Latypova Regina Sibgatullina Akihiro Ogura Katsumasa Fujiki Alsu Khabibrakhmanova Tsuyoshi Tahara Satoshi Nozaki Sayaka Urano Kazuki Tsubokura Hirotaka Onoe Yasuyoshi Watanabe Almira Kurbangalieva Katsunori Tanaka

Adv Sci (Weinh)

Biofunctional Synthetic Chemistry Laboratory RIKEN, Hirosawa Wako-shi, Saitama 351-0198 Japan; Biofunctional Chemistry Laboratory A. Butlerov Institute of Chemistry Kazan Federal University 18 Kremlyovskaya street Kazan 420008 Russia; JST-PRESTO, Hirosawa Wako-shi, Saitama 351-0198 Japan.

Published: February 2017

are prepared on albumin via a double click procedure. The number of glycan molecules present, in addition to the spatial arrangement of glycans in the heterogeneous glycoclusters, plays an important role in the in vivo kinetics and organ-selective accumulation through glycan pattern recognition mechanisms.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323863PMC
http://dx.doi.org/10.1002/advs.201600394DOI Listing

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