The increase in the incidence of extended-spectrum -lactamase- (ESBL-) producing species has become a serious problem worldwide, because of their incrimination in antibiotic resistance. The objective of this study is to investigate the resistance genes responsible for ESBL-producing species and carbapenemase-producing (CRE) isolated in Mthatha and to study their epidemiology. A prospective, descriptive study of 202 nonrepetitive samples from patients was obtained from Nelson Mandela Academic Hospital. The cultured isolates were subjected to antimicrobial susceptibility tests and the polymerase chain reaction of , , , , and genes. Overall were the majority with 169 (83.7%) species isolates, followed by with 29 (14.4%), while and were 2 (0.9%) each. The prevalence of ESBL production in all species was 117 (57.9%). ESBL-genotypic resistance is driven in Mthatha by 121 (77.1%) followed by 105 (66.9%) and at 89 (56.7%). The most common ESBL genotype combination among the was + + at 79 (50.3%). There is a steady increase in the rate of ESBL genes in the last five years.
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| http://dx.doi.org/10.1155/2017/8486742 | DOI Listing |
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