The Coordination Abilities of New Cyclic Analogs of Somatostatin.

Int J Pept Res Ther

Department of Inorganic Chemistry, Wroclaw Medical University, Borowska 211A, 50-556 Wrocław, Poland.

Published: July 2016

Two new somatostatin analogs with a characteristic part of the sequence -c(Cys-Phe-Trp-Lys-Thr-Cys)- and with two histidine and two aspartic acid moieties in their structures were synthesized and analyzed in terms of their coordination abilities with copper (II) ions. Both peptides bind Cu(II) effectively. Ligands form 4N complexes with [Formula: see text] binding mode in a basic range of pH. But in spite of very similar sequences of the two peptides a significant difference in the effectiveness of the binding of copper (II) ions was observed.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306305PMC
http://dx.doi.org/10.1007/s10989-016-9546-4DOI Listing

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