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| http://dx.doi.org/10.1523/JNEUROSCI.3778-16.2017 | DOI Listing |
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G protein-coupled receptor 17 is regulated by WNT pathway during oligodendrocyte precursor cell differentiation.
Neurobiol Dis
October 2023
Université Paris Cité, Inserm, NeuroDiderot, F-75019 Paris, France.
G protein-coupled receptor 17 (GPR17) and the WNT pathway are critical players of oligodendrocyte (OL) differentiation acting as essential timers in developing brain to achieve fully-myelinating cells. However, whether and how these two systems are related to each other is still unknown. Of interest, both factors are dysregulated in developing and adult brain diseases, including white matter injury and cancer, making the understanding of their reciprocal interactions of potential importance for identifying new targets and strategies for myelin repair.
View Article and Find Full Text PDFRewiring of Glucose and Lipid Metabolism Induced by G Protein-Coupled Receptor 17 Silencing Enables the Transition of Oligodendrocyte Progenitors to Myelinating Cells.
Cells
August 2022
Department of Pharmaceutical Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
In the mature central nervous system (CNS), oligodendrocytes (OLs) provide support and insulation to axons thanks to the production of a myelin sheath. During their maturation to myelinating cells, OLs require energy and building blocks for lipids, which implies a great investment of energy fuels and molecular sources of carbon. The oligodendroglial G protein-coupled receptor 17 (GPR17) has emerged as a key player in OL maturation; it reaches maximal expression in pre-OLs, but then it has to be internalized to allow terminal maturation.
View Article and Find Full Text PDFAdipocytokines leptin and adiponectin function as mast cell activity modulators.
Immunology
September 2019
Department of Experimental Immunology, Faculty of Health Sciences, Medical University of Lodz, Lodz, Poland.
A growing body of data indicates that adipocytokines, including leptin and adiponectin, are critical components not only of metabolic regulation but also of the immune system, mainly by influencing the activity of cells participating in immunological and inflammatory processes. As mast cells (MCs) are the key players in the course of those mechanisms, this study aimed to evaluate the impact of leptin and adiponectin on some aspects of MC activity. We documented that in vivo differentiated mature tissue MCs from the rat peritoneal cavity express a receptor for leptin (OB-R), as well as receptors for adiponectin (AdipoR1 and AdipoR2).
View Article and Find Full Text PDFGpr17, a Player in Lysolecithin-Induced Demyelination, Oligodendrocyte Survival, and Differentiation.
J Neurosci
March 2017
Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland.
Does GRK-β arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways?
Cell Signal
June 2014
Department of Pharmacy, University of Pisa, 56126 Pisa, Italy. Electronic address:
Article Synopsis
- The differentiation of oligodendrocyte-precursor cells (OPCs) is affected by the dysfunctional regulation of GPR17, which plays a role in multiple sclerosis progression.
- The study investigates how the GRK-β arrestin system influences GPR17's function, particularly how different GRK isoforms are activated by purinergic and cysLT ligands during OPC maturation.
- The findings reveal that GRK2 is essential for cysLT-induced OPC maturation, while GRK5 is specifically recruited by purinergic ligands, indicating that different ligands activate distinct signaling pathways that ultimately contribute to OPC differentiation.
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