AI Article Synopsis
- - Bronchial asthma is a chronic inflammatory disease affecting the airways, with microRNAs (miRNAs) playing a key role in its development.
- - Previous research indicates that miR-20b can help reduce airway inflammation in mice with asthma, but the specific workings behind this effect were unclear.
- - The latest study found that miR-20b nasal drops increased myeloid-derived suppressor cells (MDSCs) in the lungs of asthmatic mice and elevated TGF-β levels, suggesting miR-20b helps expand these cells in lung tissue rather than increasing their overall numbers in the body.
Article Abstract
Bronchial asthma is a common chronic airway inflammatory disease. MicroRNAs (miRNAs) play an important role in the pathogenesis of asthma. We have previously shown that miR-20b can inhibit airway inflammation in asthmatic mice, but the exact mechanism is unknown. In the present study, we show that administration of nasal drops containing miR-20b induced an increase in the percentage of Gr1CD11b myeloid-derived suppressor cells (MDSCs) in lung tissue from asthmatic mice, and the content of TGF-β in lung tissues also increased after treatment. However, there was no significant change in the number of Gr1CD11b MDSCs in bone marrow, peripheral blood, or spleens of asthmatic mice receiving the miR-20b nasal drip compared with untreated asthmatic mice. Since MDSCs originate in the bone marrow, these results suggest that miR-20b nasal drops may promote the increase of Gr1CD11b MDSCs in the lungs of asthmatic mice by the mechanism of inducing expansion.
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