The Goal: To investigate the expression of Yes-associated protein (YAP) in clear cell renal cell carcinoma (ccRCC) and its clinical/prognostic significance.
Procedures: The expression of YAP protein was evaluated in tissue microarray by immunohistochemistry. Correlation between YAP expression and clinicopathological characteristics of renal cell carcinoma was analyzed.
Results: Downregulation of YAP protein was observed in ccRCC samples (=0.0311). Downregulation of YAP expression was correlated with higher T classification, higher clinical stage, and poorer differentiation (<0.05).
Conclusions: Downregulation of YAP in clear cell renal cell carcinoma (ccRCC) may contribute to poor prognosis and progressive features.
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