[Use of Vitaprost (tablets and rectal suppositories) for patients rehabilitation after invasive diagnostic urological interventions].

The successful experience with the drug Vitaprost in the treatment of chronic prostatitis, and the emerging research evidence on the use of the drug in the treatment of urinary disorders served as a prerequisite to conduct a prospective study comparing the effectiveness of the combined application of rectal suppositories Vitaprost forte and Vitaprost tablets (production of JSC Nizhpharm, STADA CIS) in the rehabilitation of patients who had undergone invasive urologic procedures. 90 patients who underwent prostate biopsy (63) and urethrocystoscopy with bladder biopsy (27) were followed from January to July 2015. All patients were randomized to the control group (n=50) and the intervention group (n=40). Patients assigned to the control group were treated with standard anti-inflammatory therapy, and intervention group besides standard therapy received rectal suppositories Vitaprost forte for 10 days with the transition to Vitaprost pills also for 10 days. Treatment efficacy was evaluated by comparing the subjective and objective measures before and after biopsy in both groups, and rates of complications and adverse events. The both formulations of Vitaprost were well tolerated. Objective parameters (Qmax, prostate volume) in groups at 1 month did not differ significantly. However, there was a statistically significant greater reduction in subjective indicators (I-PSS, QoL) in the study group (12,4+/-1,1 and 2,1+/-0,4 points, respectively) compared with the control group (15,8+/-1,9 and 3,2+/-0,6 points, respectively). Also, patients treated with Vitaprost, had significantly higher scores in IIEF and Well-Being Index on a visual analog scale. Vitaprost use resulted in reduced risk of acute urinary retention and frequency of hematospermia. To conclude, the combined use of Vitaprost forte and Vitaprost in the rehabilitation of patients after invasive urologic interventions is beneficial in terms of improvement of patients subjective and objective indicators.