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Associations between serum levels of calcium, parathyroid hormone and future risk of venous thromboembolism: the Tromsø study. | LitMetric

AI Article Synopsis

  • This study explored the link between serum calcium and parathyroid hormone (PTH) levels with the risk of venous thromboembolism (VTE) in a large adult population over several years.
  • Researchers analyzed data from nearly 28,000 participants and recorded instances of VTE from 1994-2012, using regression models to assess risks based on varying levels of calcium and PTH.
  • Results showed that while individual levels of calcium and PTH weren't linked to VTE risk, having both high levels significantly increased the risk compared to individuals with normal levels of these substances.

Article Abstract

Objective: The relationship between serum levels of calcium, parathyroid hormone (PTH) and risk of venous thromboembolism (VTE) has not been addressed in population-based cohorts. We investigated the associations between serum levels of calcium and PTH, with future risk of VTE in a general adult population.

Design: Population-based cohort.

Methods: A total of 27 712 subjects (25-87 years) who participated in Tromsø 4 (1994-1995) and Tromsø 5 (2001-2002) surveys were included in the study, and total calcium and PTH were measured in 27 685 and 8547 subjects respectively. Incident VTE was recorded through December 31, 2012. Cox-regression models with calcium and PTH as time-varying exposures were used to calculate hazard ratios (HR) of VTE by quartiles of calcium and PTH. Quartiles of calcium and PTH were also combined to assess the effect of discordants of both PTH and calcium (e.g. highest and lowest quartiles of both calcium and PTH) on VTE risk using the middle two quartiles as reference.

Results: There were 712 VTEs during 15.0 years of median follow-up. Serum levels of calcium and PTH were not associated with risk of VTE. However, subjects with discordant high serum levels of both calcium and PTH (calcium ≥2.45 mmol/L and PTH ≥4.0 pmol/L) had increased risk of VTE compared to those in subjects with normal calcium and PTH (multivariable HR: 1.78, 95% CI: 1.12-2.84).

Conclusions: Serum levels of calcium and PTH separately were not associated with future risk of VTE, but subjects with high levels of both calcium and PTH had increased risk of VTE compared to those in subjects with normal levels.

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Source
http://dx.doi.org/10.1530/EJE-16-1037DOI Listing

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