AI Article Synopsis
- The study investigated how variations in the ELOVL gene affect the levels of polyunsaturated fatty acids (PUFAs) in breast milk from 209 healthy Han Chinese mothers.
- Carriers of certain genetic variants (SNPs rs2397142 and rs9357760) showed higher levels of key fatty acids like linoleic acid and DHA, while another variant (rs209512) was linked to lower levels of docosatetraenoic acid.
- Overall, the genetic variations in the ELOVL5 gene accounted for a small portion of the variability in breast milk fatty acid levels, indicating their role in PUFA metabolism.
Article Abstract
The present study was designed to examine the contributions of the fatty acid elongase (ELOVL) gene polymorphisms to the levels of polyunsaturated fatty acids (PUFAs) in breast milk. Two hundred and nine healthy Han Chinese mothers were included in the study. Carriers of minor alleles of SNPs (rs2397142 and rs9357760) in ELOVL5 were associated with higher levels of linoleic acid (LA), dihomo-γ-linolenic acid (DGLA), arachidonic acid (AA), docosatetraenoic acid (DTA), docosahexenoic acid (DHA), while in rs209512 of ELOVL5 the carriers of minor alleles had lower levels of DTA compared to major homozygote alleles (P ranged from 0.004-0.046), and genetically explained variability ranged from 3.2% for eicosapentaenoic acid (EPA) to 6.0% for LA. Our findings demonstrated that common variation in ELOVL5 gene encoding rate-limiting enzymes in the metabolism of PUFAs contribute to the PUFAs in breast milk.
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| http://dx.doi.org/10.3967/bes2017.008 | DOI Listing |
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