Sequential Growth of NaYF:Yb/Er@NaGdF Nanodumbbells for Dual-Modality Fluorescence and Magnetic Resonance Imaging.

ACS Appl Mater Interfaces

Department of Immunology, Department of Pathogen Biology, Provincial Laboratories of Pathogen Biology and Zoonoses Anhui, and Clinical Laboratory of the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230022, China.

Published: March 2017

Upconversional core-shell nanostructures have gained considerable attention due to their distinct enhanced fluorescence efficiency, multifunctionality, and specific applications. Recently, we have developed a sequential growth process to fabricate unique upconversion core-shell nanoparticles. Time evolution of morphology for the NaYF:Yb/Er@NaGdF nanodumbbells has been extensively investigated. An Ostwald ripening growth mechanism has been proposed to illustrate the formation of NaYF:Yb/Er@NaGdF nanodumbbells. The hydrophilic NaYF:Yb/Er@NaGdF core-shell nanodumbbells exhibited strong upconversion fluorescence and showed higher magnetic resonance longitudinal relaxivity (r = 7.81 mM s) than commercial contrast agents (Gd-DTPA). NaYF:Yb/Er@NaGdF nanodumbbells can serve as good candidates for high efficiency fluorescence and magnetic resonance imaging.

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http://dx.doi.org/10.1021/acsami.6b16842DOI Listing

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