Polypeptide complexes derived from the bronchi, blood vessels, muscles, kidneys, ovaries, testes, and retina stimulated the processes of cell renewal in organotypic cultures of the corresponding organs of young and old animals. A correlation between the intensity of regeneration and animal' age was revealed. The polypeptide complexes reduced the expression of apoptotic factors p53 and caspase 3 and increased the expression of proliferation protein Ki-67. These results provide the basis for further study of the polypeptide complexes as stimulators of regenerative processes in different tissues during ageing.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-017-3655-8 | DOI Listing |
Publication Analysis
Top Keywords
polypeptide complexes
12
polypeptides cell
4
cell proliferation
4
proliferation apoptosis
4
apoptosis aging
4
aging polypeptide
4
complexes derived
4
derived bronchi
4
bronchi blood
4
blood vessels
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!