Enantioselective synthesis of SiMe/SiPhMe-substituted crotyl geminal bis(silane) has been developed. This compound is a useful reagent for PhCB(CF)-catalyzed asymmetric Sakurai allylation and one-pot Sakurai allylation/Prins cyclization processes. Chemoselective desilylation of SiPhMe leads to efficient chirality transfer.
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| http://dx.doi.org/10.1039/c7cc00632b | DOI Listing |
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