A novel transposon belonging to the Tn-like family was identified on the chromosome of a commensal strain of sequence type 2343 (ET02). Tn is 7,367 bp long and harbors eight open reading frames (ORFs), an ATPase (IS family), a transposase (DDE catalytic type), a Tn resolvase, three hypothetical proteins, and genes encoding the new pyocin S8 with its immunity protein. We show that pyocin S8 displays activity against carbapenemase-producing , including IMP-1, SPM-1, VIM-1, GES-5, and KPC-2 producers.
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| http://dx.doi.org/10.1128/AAC.00100-17 | DOI Listing |
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