AI Article Synopsis
- DNA replication and repair are crucial for passing on genetic information and rely on cells' ability to detect and fix DNA damage through complex signaling networks.
- Post-translational modifications by proteins like ubiquitin and ISG15 play key roles in the DNA damage response (DDR) and tolerance (DDT) mechanisms.
- Recent studies highlight ISG15's importance in cellular responses to DNA damage, particularly in regulating proteins linked to growth inhibition and cancer development.
Article Abstract
Error-free replication and repair of DNA are pivotal to organisms for faithful transmission of their genetic information. Cells orchestrate complex signaling networks that sense and resolve DNA damage. Post-translational protein modifications by ubiquitin and ubiquitin-like proteins, including SUMO and NEDD8, are critically involved in DNA damage response (DDR) and DNA damage tolerance (DDT). The expression of interferon-stimulated gene 15 (ISG15), the first identified ubiquitin-like protein, has recently been shown to be induced under various DNA damage conditions, such as exposure to UV, camptothecin, and doxorubicin. Here we overview the recent findings on the role of ISG15 and its conjugation to target proteins (e.g., p53, ΔNp63α, and PCNA) in the control of cellular responses to genotoxic stress, such as the inhibition of cell growth and tumorigenesis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339507 | PMC |
| http://dx.doi.org/10.14348/molcells.2017.0027 | DOI Listing |
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