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Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs.
Front Oncol
October 2024
Enara Bio Ltd., Oxford, United Kingdom.
Background: Major histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic. MR1 presents metabolites in the context of host responses to bacterial infection. MR1-restricted TCRs specific to tumor cells have been described, raising interest in their potential therapeutic application for cancer treatment.
View Article and Find Full Text PDFExercise to combat cancer: focusing on the ends.
Physiol Genomics
December 2024
School of Health and Medical Sciences, University of Southern Queensland, Toowoomba, Queensland, Australia.
Cancer remains a leading cause of death worldwide and although prognosis and survivorship after therapy have improved significantly, current cancer treatments have long-term health consequences. For decades telomerase-mediated telomere maintenance has been an attractive anti-cancer therapeutic target due to its abundance and role in telomere maintenance, pathogenesis, and growth in neoplasms. Telomere maintenance-specific cancer therapies, however, are marred by off-target side effects that must be addressed before they reach clinical practice.
View Article and Find Full Text PDFThe Role of Antioxidant Foods and Nutraceuticals in Ageing.
Antioxidants (Basel)
July 2024
Department of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, 35131 Padova, Italy.
The free radical theory of aging proposed by Denham Harman in the 1950s identified the accumulation of oxidative damage over time as a cause of aging [...
View Article and Find Full Text PDFA novel deep learning-based method for automatic stereology of microglia cells from low magnification images.
Neurotoxicol Teratol
April 2024
Department of Computer Science and Engineering, University of South Florida, Tampa, FL 33620, USA; SRC Biosciences, Tampa, FL 33606, USA. Electronic address:
Microglial cells mediate diverse homeostatic, inflammatory, and immune processes during normal development and in response to cytotoxic challenges. During these functional activities, microglial cells undergo distinct numerical and morphological changes in different tissue volumes in both rodent and human brains. However, it remains unclear how these cytostructural changes in microglia correlate with region-specific neurochemical functions.
View Article and Find Full Text PDFDisabilities and Medicine: From Stairs to Stares.
HCA Healthc J Med
August 2023
Piedmont Macon Medical Center, Macon, GA.
Description The current state of medicine has done little to correct the imbalance of underrepresented groups in the physician workforce. In this editorial, a psychiatric resident physician retells his experience as an individual who is completing his medical training while being affected by a neuromuscular disorder and how it impacts his daily life. The primary goal of this paper is to elucidate the need for greater representation and understanding of the disabled physician workforce.
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