Combined long-term caffeine intake and exercise inhibits the development of diabetic nephropathy in OLETF rats.

J Appl Physiol (1985)

Department of Physiology, Graduate School of Health and Sports Science, Juntendo University, Inzai, Chiba, Japan.

Published: May 2017

AI Article Synopsis

  • The study investigated the impact of long-term caffeine consumption alone and with exercise on diabetic nephropathy (DN) in obese diabetic rats.
  • The rats were divided into four groups: sedentary, exercise, caffeine intake, and combined caffeine plus exercise, with the caffeine group receiving a specific dosage.
  • Results indicated that caffeine intake, whether alone or combined with exercise, did not lead to increased blood pressure and actually improved urine volume, electrolyte excretion, and renal function, suggesting potential protective effects against kidney damage in diabetic conditions.

Article Abstract

This study was performed to examine the effects of long-term caffeine-intake, with and without exercise, on the progression of diabetic nephropathy (DN) in an obese diabetic rat model. Thirty-two male Otsuka Long-Evans Tokushima fatty (OLETF) rats were assigned to sedentary (OLETF-Sed), exercise (OLETF-Ex), caffeine-intake (OLETF-Caf), and combined (OLETF-Caf + Ex) groups. Caffeine-intake groups were fed rat chow containing caffeine (90.7 ± 4.7 mg/kg/day). The OLETF-Ex and OLETF-Caf + Ex groups were able to run voluntarily at any time using a rotatory wheel. Body weight (BW) and blood pressure (BP) were measured weekly from 24 to 29 wk of age. Pre- and posttreatment serum glucose, insulin, and creatinine concentrations were measured, and a 24 h urine sample was collected for measurement of creatinine clearance (Ccr) and albumin excretion (UE). After treatment, the kidneys were removed for morphological analysis. The OLETF-Caf and OLETF-Caf + Ex groups exhibited no BP increase during the study. Both the caffeine-intake groups exhibited a significant increase in urine volume (UV), electrolyte excretion, and Ccr, and decreased UE, following treatment. Furthermore, no structural damage was observed in the kidneys of rats from either caffeine-intake group, whereas the OLETF-Sed and OLETF-Ex groups exhibited DN progression. This study demonstrates that caffeine-intake alone and/or combined with exercise significantly decreases BW and improves glucose intolerance, without the progression of DN. Further research should be performed to examine whether the quantities of caffeine contained in a normal human daily intake also have a protective effect against kidney damage. The present study showed that caffeine administration alone and/or combined with exercise results in an improvement of diabetic nephropathy (DN), including an increase in creatinine clearance and urinary Na excretion, a decrease in urinary protein excretion, and in renal morphological findings. To our knowledge, there are no other studies showing that caffeine administration inhibits DN progression.

Download full-text PDF

Source
http://dx.doi.org/10.1152/japplphysiol.00278.2016DOI Listing

Publication Analysis

Top Keywords

diabetic nephropathy
12
oletf-caf groups
12
groups exhibited
12
oletf rats
8
performed examine
8
caffeine-intake groups
8
creatinine clearance
8
exhibited increase
8
and/or combined
8
combined exercise
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!