AI Article Synopsis
- Patients with pathological health anxiety (PHA) show a heightened attentional bias toward health-related words, indicating their stronger focus on health threats compared to control groups.
- fMRI results revealed increased activation in brain areas like the amygdala and rostral anterior cingulate cortex when patients with PHA were exposed to body symptom words, linking this bias to emotional responses.
- The study highlights the need for targeted treatment approaches and better classification of PHA, although it suggests that including a more varied anxiety control group would strengthen the findings.
Article Abstract
Background: An attentional bias to health-threat stimuli is assumed to represent the primary pathogenetic factor for the development and maintenance of pathological health anxiety (PHA; formerly termed "hypochondriasis"). However, little is known about the neural basis of this attentional bias in individuals with PHA.
Methods: A group of patients with PHA, a group of depressed patients and a healthy control group completed an emotional Stroop task with health-threat (body symptom and illness) words and neutral control words while undergoing functional MRI.
Results: We included 33 patients with PHA, 28 depressed patients and 31 controls in our analyses. As reflected in reaction times, patients with PHA showed a significantly stronger attentional bias to health-threat words than both control groups. In addition, patients with PHA showed increased amygdala and rostral anterior cingulate cortex activation for body symptom, but not for illness words. Moreover, only in patients with PHA amygdala activation in response to symptom words was positively associated with higher arousal and more negative valence ratings of the body symptom word material.
Limitations: A control group of patients with an anxiety disorder but without PHA would have helped to define the specificity of the results for PHA.
Conclusion: The attentional bias observed in patients with PHA is associated with hyperactivation in response to body symptom words in brain regions that are crucial for an arousal-related fear response (e.g., the amygdala) and for resolving emotional interference (e.g., the rostral anterior cingulate cortex). The findings have important implications for the nosological classification of PHA and suggest the application of innovative exposure-based interventions for the treatment of PHA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403665 | PMC |
| http://dx.doi.org/10.1503/jpn.160081 | DOI Listing |
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