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Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel.
Ticks Tick Borne Dis
December 2024
Krankenhaus Nordwest, Frankfurt, Germany.
Categorization systems for tick-borne encephalitis virus (TBEV) infection lack consistency in classifying disease severity. To evaluate the need for a standard, consensus-based categorisation system for TBEV infection across subtypes, we gathered an expert panel of clinicians and scientists with diverse expertise in TBEV infection. Consensus was sought using the Delphi technique, which consisted of 2 web-based survey questionnaires and a final, virtual, consensus-building exercise.
View Article and Find Full Text PDFDo We Need a Lyme Disease Vaccine?
Pediatr Infect Dis J
January 2025
From the Department of Pediatrics, University of Pennsylvania, Doylestown, Pennsylvania.
A core genome MLST scheme for Borrelia burgdorferi sensu lato improves insights into the evolutionary history of the species complex.
Cell Rep Methods
December 2024
German National Reference Centre for Borrelia, Oberschleissheim, Germany; Bavarian Health and Food Safety Authority, Oberschleissheim, Germany.
Multi-locus sequence typing (MLST) based on eight genes has become the method of choice for Borrelia typing and is extensively used for population studies. Whole-genome sequencing enables studies to scale up to genomic levels but necessitates extended schemes. We have developed a 639-loci core genome MLST (cgMLST) scheme for Borrelia burgdorferi sensu lato (s.
View Article and Find Full Text PDFAlzheimer's disease-associated CD83(+) microglia are linked with increased immunoglobulin G4 and human cytomegalovirus in the gut, vagal nerve, and brain.
Alzheimers Dement
December 2024
Banner Alzheimer's Institute, Phoenix, Arizona, USA.
Introduction: While there may be microbial contributions to Alzheimer's disease (AD), findings have been inconclusive. We recently reported an AD-associated CD83(+) microglia subtype associated with increased immunoglobulin G4 (IgG4) in the transverse colon (TC).
Methods: We used immunohistochemistry (IHC), IgG4 repertoire profiling, and brain organoid experiments to explore this association.
Transverse Myelitis in a Healthy Adult Female Patient: A Rare Viral Etiology.
Cureus
November 2024
Internal Medicine, Baptist Health South Florida, Miami, USA.
Transverse myelitis (TM) is an uncommon but extensively documented neurological disorder marked by acute spinal cord inflammation, resulting in a spectrum of impairments including motor, sensory, and autonomic disturbances. We outline a rare case of viral-induced TM linked to COVID-19 and Coxsackie B viral infections. A 25-year-old healthy female patient presented with acute bilateral upper and lower extremity weakness, paresthesia, and urinary retention.
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